Rajput A H, Uitti R J, Stern W, Laverty W, O'Donnell K, O'Donnell D, Yuen W K, Dua A
Department of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan, Canada.
Can J Neurol Sci. 1987 Aug;14(3 Suppl):414-8. doi: 10.1017/s0317167100037823.
In 1984 we made the first observation of a correlation between early age exposure to rural environment (and drinking well water) and development of idiopathic Parkinson's disease (IPD). These findings were subsequently confirmed elsewhere (Barbeau, 1985;25 Tanner, 1985). Analysis of all early age onset IPD (EPD) cases born and raised in Saskatchewan revealed that 20 of 22 had exclusively rural exposure during the first 15 years of life. This distribution was significantly different from the general population (p = 0.0141). Further study of the EPD group included sampling and metal analysis of childhood sources of drinking water in 18 cases and 36 age and sex-matched controls. Water collected from the two groups was analyzed for 23 metals (including 7 elements implicated in the etiology of IPD). There was no difference in the metal composition of the water between the two groups. Finally, a review of herbicide and pesticide use in Saskatchewan agriculture was undertaken to determine if there was an increased incidence of EPD following utilization of any particular chemical. No increase was found in the incidence of EPD with the introduction of any pesticide or herbicide, including Paraquat, for agricultural use. We conclude that there is a strong correlation between early age rural environmental exposure and development of IPD. We believe well water is a likely vehicle for the causal agent, but neither water metal concentration nor any of the herbicides and pesticides used in Saskatchewan agriculture are related to the cause.
1984年，我们首次观察到早年接触农村环境（以及饮用井水）与特发性帕金森病（IPD）的发病之间存在关联。这些发现随后在其他地方得到了证实（巴博，1985年；坦纳，1985年）。对所有在萨斯喀彻温省出生并长大的早发性IPD（EPD）病例进行分析后发现，22例中的20例在生命的前15年中只接触过农村环境。这种分布与普通人群有显著差异（p = 0.0141）。对EPD组的进一步研究包括对18例病例和36例年龄及性别匹配的对照儿童饮用水源进行采样和金属分析。对两组采集的水分析了23种金属（包括7种与IPD病因有关的元素）。两组水的金属成分没有差异。最后，对萨斯喀彻温省农业中除草剂和杀虫剂的使用情况进行了审查，以确定使用任何特定化学品后EPD的发病率是否增加。在引入任何农药或除草剂（包括用于农业的百草枯）后，EPD的发病率均未增加。我们得出结论，早年农村环境暴露与IPD的发病之间存在很强的相关性。我们认为井水可能是致病因子的载体，但水的金属浓度以及萨斯喀彻温省农业中使用的任何除草剂和杀虫剂均与病因无关。
