Research Centre for Biomedical Engineering, School of Science and Technology, University of London, Northampton Square, London EC1V 0HB, UK.
Int J Mol Sci. 2023 Feb 3;24(3):2980. doi: 10.3390/ijms24032980.
Ethanol intoxication, although an elemental part of life in many places around the world, still presents several issues associated with excessive consumption. These issues range from drunk driving, violence, and antisocial behavior to self-harm, all exerting an increased cost on the society. Monitoring of intoxication levels can help to limit the impact of these issues by preventing the use of automobiles or heavy machinery and personal monitoring. Previous works on noninvasive measurement of ethanol tissue concentration for estimation of blood alcohol concentration (BAC) performed worst during the first hour of intoxication. Gas chromatography research of intoxication shows that levels of acetic acid rise together at a similar rate as those of ethanol after initial imbibement. In this research, short-wave infrared (SWIR) spectroscopy was utilized with the aim of establishing the interaction between ethanol and acetic acid in water and serum mixtures. The most consistent and clear correlation between ethanol and acetic acid was recorded at 2262 and 2302 nm wavelengths. Partial least-squares (PLS) analysis indicates that the most effective region for consideration in measurement of ethanol is the therapeutic window four (IV) due to high variance in vibration of carbon bonds. The behavior of spectra at different concentration ranges was examined and described in detail in relation to the consequence of alcohol measurement. The investigation concluded that ethanol shows distinctive regions of absorbance at wavelengths of 2262 and 2302 nm, with variations arising from increasing concentrations of acetic acid, whilst also showing that therapeutic window four is amongst the most influential regions of the spectrum for SWIR.
乙醇中毒虽然在世界上许多地方都是生活中不可或缺的一部分，但仍存在与过度消费相关的一些问题。这些问题从酒后驾车、暴力和反社会行为到自残，都给社会带来了更高的成本。监测中毒水平有助于通过防止使用汽车或重型机械和个人监测来限制这些问题的影响。以前关于非侵入性测量乙醇组织浓度以估计血液酒精浓度 (BAC) 的工作在中毒的最初一小时表现最差。对中毒的气相色谱研究表明，在最初摄入后，乙酸水平与乙醇一起以相似的速率上升。在这项研究中，利用短波近红外 (SWIR) 光谱来建立乙醇和乙酸在水和血清混合物中的相互作用。在 2262 和 2302nm 波长处记录到乙醇和乙酸之间最一致和清晰的相关性。偏最小二乘 (PLS) 分析表明，在考虑测量乙醇的有效区域时，由于碳键振动的高度变化，治疗窗四 (IV) 是最有效的区域。研究了不同浓度范围的光谱行为，并详细描述了与酒精测量结果相关的行为。研究得出的结论是，乙醇在 2262nm 和 2302nm 波长处显示出独特的吸收区域，随着乙酸浓度的增加而产生变化，同时还表明治疗窗四是 SWIR 光谱中最具影响力的区域之一。
