Makris Michael, Kanelleas Antonios, Papapostolou Niki, Pisimisi Maria, Katoulis Alexander C
Allergy Unit "D.Kalogeromitros", 2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, University General Hospital "Attikon",12462 Athens, Greece.
2nd Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, University General Hospital "Attikon", 12462 Athens, Greece.
J Clin Med. 2023 Jan 20;12(3):831. doi: 10.3390/jcm12030831.
Acute Localized Exanthematous Pustulosis (ALEP) is a rare skin reaction characterized by the sudden onset of multiple, small, sterile, non-follicular pustules in an erythematous and edematous base succeeding systemic drug administration. ALEP is considered a subtype of Acute Generalized Exanthematous Pustulosis (AGEP), although the exact pathogenic mechanism of the disease remains poorly defined. Numerous drugs have been implicated in the pathogenesis of ALEP, while contact mechanisms have also been reported. Herein, we describe the first case of ALEP attributed to minoxidil in a female patient with androgenetic alopecia. The positivity of patch tests and the topical application of minoxidil proposes a contact-induced hypersensitivity reaction. Identifying new agents-including minoxidil-which serve as inducers of drug-specific T-cell-mediated responses in the clinical spectrum of ALEP, adds further value in understanding the complex, yet unknown, pathophysiological mechanisms of this rare drug hypersensitivity reaction.
急性局限性发疹性脓疱病（ALEP）是一种罕见的皮肤反应，其特征为在全身用药后，在红斑和水肿的基础上突然出现多个小的、无菌的、非毛囊性脓疱。尽管该病的确切致病机制仍不明确，但ALEP被认为是急性泛发性发疹性脓疱病（AGEP）的一种亚型。许多药物与ALEP的发病机制有关，同时也有接触机制的报道。在此，我们描述了首例因米诺地尔导致的ALEP病例，该患者为一名患有雄激素性脱发的女性。斑贴试验阳性以及米诺地尔的局部应用提示了接触性超敏反应。在ALEP临床谱中，识别包括米诺地尔在内的可引发药物特异性T细胞介导反应的新药物，对于理解这种罕见药物超敏反应复杂但未知的病理生理机制具有重要价值。
