Wylęgała Adam, Roszkowska Anna M, Kokot Joanna, Dobrowolski Dariusz, Wylęgała Edward
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences, Medical University of Silesia, 40-055 Katowice, Poland.
Ophthalmology Department, Railway Hospital, 40-760 Katowice, Poland.
J Clin Med. 2023 Feb 1;12(3):1158. doi: 10.3390/jcm12031158.
To evaluate the clinical outcome, efficacy, and safety of femtosecond laser-assisted anterior lamellar keratoplasty.
In this prospective study, 21 males and 10 females aged from 15 to 62 years (mean 38.5) with different pathologies of the anterior corneal layers were enrolled for anterior lamellar keratoplasty using femtosecond laser VisuMax (Carl Zeiss, Germany). All patients were examined for uncorrected (UCVA) and best-corrected (BCVA) distance and near visual acuity, astigmatism, endothelial cell density, corneal thickness, and intraocular pressure. These examinations were performed before transplantation, at hospital discharge, and after 3 and 12 months. The mean follow-up time was 65.36 ± 28.54 months.
A statistically significant improvement of both UCVA and BCVA for distance and near vision was registered. BCVA improved from 0.11 preoperatively to 0.168 ( = 0.03), 0.267 ( < 0.01), and 0.472 ( < 0.01) on the hospital discharge day, three months, and 12 months respectively. There were no statistically significant differences in astigmatism, intraocular pressure, endothelial cell density, and corneal pachymetry as compared to preoperative and postoperative values. Six patients (19%) had a graft failure with a rate of 33% at 26 months.
Femtosecond laser-assisted anterior lamellar keratoplasty is a safe and effective surgical method, providing satisfactory graft survival rates.
评估飞秒激光辅助前板层角膜移植术的临床疗效、有效性和安全性。
在这项前瞻性研究中，纳入了21名男性和10名女性，年龄在15至62岁之间（平均38.5岁），患有不同的前角膜层病变，使用德国卡尔蔡司公司的VisuMax飞秒激光进行前板层角膜移植术。所有患者均接受未矫正（UCVA）和最佳矫正（BCVA）的远视力和近视力、散光、内皮细胞密度、角膜厚度和眼压检查。这些检查在移植前、出院时以及3个月和12个月后进行。平均随访时间为65.36±28.54个月。
远视力和近视力的UCVA和BCVA均有统计学意义的改善。BCVA分别从术前的0.11提高到出院当天的0.168（P = 0.03）、3个月时的0.267（P < 0.01）和12个月时的0.472（P < 0.01）。与术前和术后值相比，散光、眼压、内皮细胞密度和角膜测厚无统计学显著差异。6名患者（19%）发生移植失败，26个月时失败率为33%。
飞秒激光辅助前板层角膜移植术是一种安全有效的手术方法，移植存活率令人满意。
