Bajić Dejana, Matijašević Jovan, Andrijević Ljiljana, Zarić Bojan, Lalić-Popović Mladena, Andrijević Ilija, Todorović Nemanja, Mihajlović Andrea, Tapavički Borislav, Ostojić Jelena
Department of Biochemistry, Faculty of Medicine, University of Novi Sad, Street Hajduk Veljkova 3, 21137 Novi Sad, Serbia.
Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana Street 4, 21204 Sremska Kamenica, Serbia.
J Clin Med. 2023 Feb 2;12(3):1197. doi: 10.3390/jcm12031197.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and one group of patients has developed a severe form of COVID-19 pneumonia with an urgent need for hospitalization and intensive care unit (ICU) admission. The aim of our study was to evaluate the prognostic role of MDW, CRP, procalcitonin (PCT), and lactate in critically ill COVID-19 patients. The primary outcome of interest is the 28 day mortality of ICU patients with confirmed SARS-CoV-2 infection and sepsis (according to Sepsis 3 criteria with acute change in SOFA score ≥ 2 points). Patients were divided into two groups according to survival on the 28th day after admission to the ICU. Every group was divided into two subgroups (women and men). Nonparametric tests (Mann-Whitney) for variables age, PCT, lactate, and MDW were lower than alpha < 0.05, so there was a significant difference between survived and deceased patients. The Chi-square test confirmed statistically significant higher values of MDW and lactate in the non-survivor group. We found a significant association between MDW, lactate, procalcitonin, and fatal outcome, higher values were reported in the deceased group.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了全球大流行，其中一组患者出现了严重形式的新冠肺炎，急需住院治疗并入住重症监护病房（ICU）。我们研究的目的是评估平均血小板体积（MDW）、C反应蛋白（CRP）、降钙素原（PCT）和乳酸在危重症新冠肺炎患者中的预后作用。主要关注的结果是确诊感染SARS-CoV-2且患有脓毒症（根据脓毒症3标准，序贯器官衰竭评估（SOFA）评分急性变化≥2分）的ICU患者的28天死亡率。根据入住ICU后第28天的生存情况将患者分为两组。每组再分为两个亚组（女性和男性）。对年龄、PCT、乳酸和MDW变量进行非参数检验（曼-惠特尼检验），结果低于α<0.05，因此存活患者和死亡患者之间存在显著差异。卡方检验证实非存活组的MDW和乳酸值在统计学上显著更高。我们发现MDW、乳酸、降钙素原与致命结局之间存在显著关联，死亡组的这些值更高。
