Kudlinski Bartosz, Zgoła Dominika, Stolińska Marta, Murkos Magdalena, Kania Jagoda, Nowak Pawel, Noga Anna, Wojciech Magdalena, Zaborniak Gabriel, Zembron-Lacny Agnieszka
Department of Anaesthesiology, Intensive Care and Emergency Medicine, Collegium Medicum University of Zielona Góra, 65-417 Zielona Gora, Poland.
Student Research Group, University of Zielona Gora, 65-417 Zielona Gora, Poland.
Diagnostics (Basel). 2022 Mar 30;12(4):859. doi: 10.3390/diagnostics12040859.
The purpose of this study was to investigate whether routine blood tests and clinical characteristics can predict in-hospital mortality in COVID-19. Clinical data of 285 patients aged 59.7 ± 10.3 yrs. (males n = 189, females n = 96) were retrospectively collected from December 2020 to June 2021. Routine blood tests were recorded within the 1st hour of admission to hospital. The inflammatory variables, such as C-reactive protein (CRP), procalcitonin (PCT), neutrophils−lymphocyte ratio (NLR) and the systemic inflammatory index (SII), exceeded the reference values in all patients and were significantly higher in deceased patients (n = 108) compared to survivors (n = 177). The log-rank test for comparing two survival curves showed that patients aged ≥60.5 years, with PCT ≥ 0.188 ng/mL or NLR ≥ 11.57 103/µL were at a greater risk of death. NLR demonstrated a high impact on the COVID-19 mortality (HR 1.317; 95%CI 1.004−1.728; p < 0.05), whereas CRP and SII showed no effect (HR 1.000; 95%CI 1.000−1.004; p = 0.085 and HR 1.078; 95%CI 0.865−1.344; p = 0.503, respectively). In the first Polish study including COVID-19 patients, we demonstrated that age in relation to simple parameters derived from complete blood cell count has prognostic implications in the course of COVID-19 and can identify the patients at a higher risk of in-hospital mortality.
本研究的目的是调查常规血液检查和临床特征是否能够预测新型冠状病毒肺炎（COVID-19）患者的院内死亡率。回顾性收集了2020年12月至2021年6月期间285例年龄为59.7±10.3岁患者（男性189例，女性96例）的临床数据。入院后第1小时内记录常规血液检查结果。所有患者的炎症指标，如C反应蛋白（CRP）、降钙素原（PCT）、中性粒细胞与淋巴细胞比值（NLR）和全身炎症指数（SII）均超过参考值，与存活患者（n = 177）相比，死亡患者（n = 108）的这些指标显著更高。比较两条生存曲线的对数秩检验显示，年龄≥60.5岁、PCT≥0.188 ng/mL或NLR≥11.57×10³/µL的患者死亡风险更高。NLR对COVID-19死亡率有较高影响（风险比[HR] 1.317；95%置信区间[CI] 1.004−1.728；p < 0.05），而CRP和SII则无影响（HR 1.000；95%CI 1.000−1.004；p = 0.085和HR 1.078；95%CI 0.865−1.344；p = 0.503）。在第一项纳入COVID-19患者的波兰研究中，我们证明，与从全血细胞计数得出的简单参数相关的年龄对COVID-19病程具有预后意义，并且能够识别出院内死亡风险较高的患者。
