Kosmo M A, Mitsuyasu R T, Sparkes R S, Gale R P
Department of Medicine, UCLA School of Medicine 90024.
Cancer Genet Cytogenet. 1987 Dec;29(2):245-51. doi: 10.1016/0165-4608(87)90235-4.
Cytogenetic abnormalities have been reported in lymphoproliferative disorders, the most common of which is the t(8;14) translocation in Burkitt and Burkitt-like lymphomas. We report a 30-year-old homosexual male with Burkitt-like lymphoma and trisomy 12. This patient presented with persistent generalized lymphadenopathy and subsequently developed advanced lymphoma. Cell surface markers revealed a monoclonal pattern containing mu heavy chain and kappa light chain immunoglobulins. Cytogenetic analysis of bone marrow involved with lymphoma revealed an additional chromosome #12. Mitogen-stimulated cultures of peripheral blood showed a normal 46,XY karyotype. Trisomy 12 has been found in chronic lymphocytic leukemia and in other low-grade B-cell lymphoproliferative disorders, but not in Burkitt-like lymphoma.
细胞遗传学异常在淋巴增殖性疾病中已有报道，其中最常见的是伯基特淋巴瘤和伯基特样淋巴瘤中的t(8;14)易位。我们报告一名30岁的同性恋男性，患有伯基特样淋巴瘤和12号染色体三体。该患者表现为持续性全身淋巴结肿大，随后发展为晚期淋巴瘤。细胞表面标志物显示出包含μ重链和κ轻链免疫球蛋白的单克隆模式。对受累淋巴瘤的骨髓进行细胞遗传学分析发现额外一条12号染色体。外周血经丝裂原刺激培养显示正常的46,XY核型。12号染色体三体已在慢性淋巴细胞白血病和其他低级别B细胞淋巴增殖性疾病中发现，但在伯基特样淋巴瘤中未发现。
