一名患有获得性免疫缺陷综合征的同性恋男性，患有伴有8号和14号染色体易位及爱泼斯坦-巴尔病毒核相关抗原的小无裂B细胞伯基特样淋巴瘤。

Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome.

作者信息

Petersen J M, Tubbs R R, Savage R A, Calabrese L C, Proffitt M R, Manolova Y, Manolov G, Shumaker A, Tatsumi E, McClain K

出版信息

Am J Med. 1985 Jan;78(1):141-8. doi: 10.1016/0002-9343(85)90475-9.

DOI:10.1016/0002-9343(85)90475-9

PMID:2981469

Abstract

This case report describes new manifestations of the acquired immune deficiency syndrome (AIDS) in a promiscuous homosexual man. Investigation of upper gastrointestinal bleeding in the patient lead to discovery of a high-grade, small, noncleaved cell (Burkitt-like) gastroduodenal lymphoma with visceral and extralymphatic extension. Specific phenotyping of the lymphoma revealed that it was a monoclonal B cell lymphoma of mu kappa isotype. An in vitro cell line was established that was Epstein-Barr virus nuclear-associated antigen-positive. The lymphoma cells displayed a t(8;14) translocation similar to endemic African Burkitt lymphoma. Epstein-Barr virus genomes were identified in the lymphoma and an axillary lymph node biopsy specimen by molecular hybridization. These data strongly suggest that Epstein-Barr virus actively infected this patient. However, he showed normal Epstein-Barr virus-specific serologic responses, indicating an immune defect against the virus.

摘要

本病例报告描述了一名滥交同性恋男性获得性免疫缺陷综合征（艾滋病）的新表现。对该患者上消化道出血的调查发现了一种高级别、小的、非裂细胞（伯基特样）胃十二指肠淋巴瘤，并伴有内脏和淋巴外扩散。淋巴瘤的特异性表型分析显示它是一种μκ同种型的单克隆B细胞淋巴瘤。建立了一种体外细胞系，该细胞系为EB病毒核相关抗原阳性。淋巴瘤细胞显示出与地方性非洲伯基特淋巴瘤相似的t(8;14)易位。通过分子杂交在淋巴瘤和腋窝淋巴结活检标本中鉴定出EB病毒基因组。这些数据强烈表明EB病毒主动感染了该患者。然而，他显示出正常的EB病毒特异性血清学反应，表明对该病毒存在免疫缺陷。