Koppány Ferenc, Csomó Krisztián Benedek, Varmuzsa Edvárd Márton, Bognár Eszter, Pelyhe Liza, Nagy Péter, Kientzl Imre, Szabó Dániel, Weszl Miklós, Dobos Gábor, Lenk Sándor, Erdei Gábor, Kiss Gábor, Nagy Lilien, Sréter Attila, Belik Andrea Alexandra, Tóth Zsuzsanna, Vág János, Joób-Fancsaly Árpád, Németh Zsolt
Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, 1085 Budapest, Hungary.
FERR-VÁZ Kft, 1161 Budapest, Hungary.
Nanomaterials (Basel). 2023 Jan 27;13(3):511. doi: 10.3390/nano13030511.
Our research group developed a novel nano-pitted (NP) TiO surface on grade 2 titanium that showed good mechanical, osteogenic, and antibacterial properties; however, it showed weak hydrophilicity. Our objective was to develop a surface treatment method to enhance the hydrophilicity of the NP TiO surface without the destruction of the nano-topography. The effects of dilute and concentrated orthophosphoric (HPO) and nitric acids were investigated on wettability using contact angle measurement. Optical profilometry and atomic force microscopy were used for surface roughness measurement. The chemical composition of the TiO surface and the oxidation state of Ti was investigated using X-ray photoelectron spectroscopy. The ccHPO treatment significantly increased the wettability of the NP TiO surfaces (30°) compared to the untreated control (88°). The quantity of the absorbed phosphorus significantly increased following ccHPO treatment compared to the control and caused the oxidation state of titanium to decrease (Ti → Ti). Owing to its simplicity and robustness the presented surface treatment method may be utilized in the industrial-scale manufacturing of titanium implants.
我们的研究小组在2级钛上开发了一种新型纳米凹坑（NP）TiO表面，该表面具有良好的机械性能、成骨性能和抗菌性能；然而，它的亲水性较弱。我们的目标是开发一种表面处理方法，以增强NP TiO表面的亲水性，同时不破坏纳米形貌。使用接触角测量研究了稀磷酸（HPO）和浓硝酸对润湿性的影响。使用光学轮廓仪和原子力显微镜测量表面粗糙度。使用X射线光电子能谱研究TiO表面的化学成分和Ti的氧化态。与未处理的对照（88°）相比，ccHPO处理显著提高了NP TiO表面的润湿性（30°）。与对照相比，ccHPO处理后吸收的磷量显著增加，并导致钛的氧化态降低（Ti→Ti）。由于其简单性和稳健性，所提出的表面处理方法可用于钛植入物的工业规模制造。
