Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong, SAR PR China.
Clin Oral Implants Res. 2011 Apr;22(4):349-56. doi: 10.1111/j.1600-0501.2011.02172.x.
To evaluate the rate and degree of osseointegration at chemically modified moderately rough, hydrophilic (SLActive) and moderately rough, hydrophobic (SLA) implant surfaces during early phases of healing in a human model.
The devices used for this study of early healing were 4 mm long and 2.8 mm in diameter and had either an SLActive chemically modified or a moderately rough SLA surface configuration. These devices were surgically installed into the retro-molar area of 49 human volunteers and retrieved after 7, 14, 28 and 42 days of submerged healing. A 5.2-mm-long specially designed trephine with a 4.9 mm inside diameter, allowing the circumferential sampling of 1 mm tissue together with the device was applied. Histologic ground sections were prepared and histometric analyses of the tissue components (i.e. old bone, new bone, bone debris and soft tissue) in contact with the device surfaces were performed.
All device sites healed uneventfully. All device surfaces were partially coated with bone debris. A significant fraction of this bone matrix coating became increasingly covered with newly formed bone. The process of new bone formation started already during the first week in the trabecular regions and increased gradually up to 42 days. The percentage of direct contact between newly formed bone and the device (bone-to-implant contact) after 2 and 4 weeks was more pronounced adjacent to the SLActive than to the SLA surface (14.8% vs. 12.2% and 48.3% vs. 32.4%, respectively), but after 42 days, these differences were no longer evident (61.6% vs. 61.5%).
While healing showed similar characteristics with bone resorptive and appositional events for both SLActive and SLA surfaces between 7 and 42 days, the degree of osseointegration after 2 and 4 weeks was superior for the SLActive compared with the SLA surface.
评估在人体模型的早期愈合阶段，经化学改性的中等粗糙度、亲水（SLActive）和中等粗糙度、疏水性（SLA）种植体表面的骨整合速率和程度。
本研究中使用的早期愈合装置长 4 毫米，直径 2.8 毫米，具有 SLActive 化学改性或中等粗糙度 SLA 表面结构。这些装置被手术植入 49 名志愿者的磨牙后区，并在水下愈合 7、14、28 和 42 天后取出。使用一个 5.2 毫米长的特殊设计的环钻，内径为 4.9 毫米，允许环周取样 1 毫米组织与装置一起使用。制备组织学磨片，并对与装置表面接触的组织成分（即旧骨、新骨、骨碎片和软组织）进行组织计量分析。
所有装置部位均愈合顺利。所有装置表面均部分覆盖有骨碎片。这种骨基质涂层的很大一部分逐渐被新形成的骨覆盖。新骨形成的过程在小梁区的第一周就已经开始，并逐渐增加到 42 天。在 2 周和 4 周时，新形成的骨与装置之间的直接接触百分比（骨-种植体接触）在 SLActive 表面比在 SLA 表面更明显（分别为 14.8%比 12.2%和 48.3%比 32.4%），但在 42 天后，这些差异不再明显（分别为 61.6%比 61.5%）。
在 7 至 42 天之间，SLActive 和 SLA 表面的愈合均表现出相似的骨吸收和骨形成特征，但在 2 周和 4 周时，SLActive 表面的骨整合程度优于 SLA 表面。
