Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Tamilnadu, 603103, India.
Mol Biol Rep. 2024 Sep 4;51(1):955. doi: 10.1007/s11033-024-09888-6.
Over time, researchers have accumulated significant evidence indicating that vitamin D deficiency not only impacts skeletal health but also contributes to the development and progression of various diseases, including cancer, diabetes, and cardiovascular conditions. The risk of low serum 1, 25(OH)2D3 level ultimately directs the way to morbidity, the beginning of new diseases, and numerous infections. Infections are the first entity that affects those with vitamin D deficiency. The common infection is urinary tract infection (UTI), and its relationship with vitamin D deficiency or insufficiency remains controversial. This infection affects both men and women, but comparatively, women are more prone to this infection because of the short length of the urethra, which makes an easy entry for the bacteria. The low level of serum vitamin D increases the risk of UTIs in children. Recurrent UTIs are one of the major weaknesses in women; if left untreated, they progress to appallingly serious conditions like kidney dysfunction, liver damage, etc. Hence improving the vitamin D status may help to improve the immune system, thus making it more resistant to infections. In this review, we have focused on examining whether vitamin D deficiency and insufficiency are the causes of UTIs and the association between them in women and children. We have also described the connection between vitamin D deficiency and insufficiency with UTIs and additional nanotechnology- based treatment strategies.
随着时间的推移，研究人员积累了大量证据表明，维生素 D 缺乏不仅会影响骨骼健康，还会导致各种疾病的发生和发展，包括癌症、糖尿病和心血管疾病。低血清 1,25(OH)2D3 水平的风险最终会导致发病率、新疾病的开始和许多感染。感染是影响维生素 D 缺乏者的第一个实体。常见的感染是尿路感染 (UTI)，其与维生素 D 缺乏或不足的关系仍存在争议。这种感染影响男女，但相对而言，由于尿道较短，女性更容易受到这种感染，这使得细菌很容易进入。血清维生素 D 水平低会增加儿童患尿路感染的风险。复发性尿路感染是女性的主要弱点之一；如果不治疗，它们会发展成严重的肾脏功能障碍、肝脏损伤等。因此，改善维生素 D 状况可能有助于增强免疫系统，使其更能抵抗感染。在这篇综述中，我们重点研究了维生素 D 缺乏和不足是否是尿路感染的原因，以及它们在女性和儿童中的关联。我们还描述了维生素 D 缺乏和不足与尿路感染之间的联系以及基于纳米技术的额外治疗策略。
