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黄连和胡黄连叶、花、茎、根提取物对 的生存影响。

Effect of L. and L. Leaf, Flower, Stem, and Root Extracts on the Survival of .

机构信息

Department of Biochemistry, Faculty of Science, Charles University, Hlavova 2030, 128 43 Prague, Czech Republic.

出版信息

Molecules. 2023 Jan 19;28(3):1019. doi: 10.3390/molecules28031019.

Abstract

is one of the most antibiotic multi-resistant bacteria, causing chronic pulmonary disease and leading to respiratory failure and even mortality. Thus, there has been an ever-increasing search for novel and preferably natural antimicrobial compounds. L. and L. shoots are commonly used as teas or alcoholic tinctures for their human health-promoting and antibacterial properties. Here, we explored the antimicrobial effects of all plant parts, i.e., leaf, flower, stem, and root extracts, prepared in water or in 60% ethanol, against . The impact of these extracts on bacterial survival was determined using a luminescent strain of , which emits light when alive. In addition, the antimicrobial effects were compared with the antioxidant properties and content of phenolic compounds of plant extracts. Ethanolic extracts of roots and flowers showed the highest antimicrobial activity, followed by roots. In particular, chlorogenic acid, the ethanolic extract of roots contained high levels of protocatechuic acid, hesperidin, shikimic acid, rutin, quercetin, and morin. The synergistic effects of these phenolic compounds and flavonoids may play a key role in the antibacterial activity of teas and tinctures.

摘要

是最具抗生素耐药性的细菌之一,可导致慢性肺部疾病,引起呼吸衰竭甚至死亡。因此,人们一直在不断寻找新型的、最好是天然的抗菌化合物。L.和L.的嫩枝常被用作茶或酒精酊剂,因其具有促进人体健康和抗菌的特性。在这里,我们研究了所有植物部分(叶、花、茎和根提取物)的抗菌作用,这些提取物分别用水或 60%乙醇制备,以对抗。使用发光的细菌菌株来确定这些提取物对细菌存活的影响,当细菌存活时,该菌株会发光。此外,还比较了植物提取物的抗氧化特性和酚类化合物含量与抗菌作用的关系。根和花的乙醇提取物表现出最高的抗菌活性,其次是根。特别是根的乙醇提取物含有高水平的绿原酸、原儿茶酸、柚皮苷、莽草酸、芦丁、槲皮素和桑色素。这些酚类化合物和类黄酮的协同作用可能在茶和酊剂的抗菌活性中发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/9921178/77c4e709cbc0/molecules-28-01019-g001.jpg

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