Dipartimento di Chimica "Giacomo Ciamician", Università di Bologna, 40126 Bologna, Italy.
School of Chemical Engineering, Zhengzhou University, Zhengzou 450001, China.
Molecules. 2023 Jan 27;28(3):1244. doi: 10.3390/molecules28031244.
Co-crystallization of kojic acid (HKA) with silver(I), copper(II), zinc(II), or gallium(III) salts yielded three 1D coordination polymers and one 0D complex in which kojic acid was present as a neutral or anionic terminal or bridging ligand. All reactions were conducted mechanochemically via ball milling and manual grinding, or via slurry. All solids were fully characterized via single-crystal and/or powder X-ray diffraction. As kojic acid is a mild antimicrobial compound that is widely used in cosmetics, and the metal cations possess antibacterial properties, their combinations were tested for potential antibacterial applications. The minimal inhibition concentrations (MICs) and minimal biocidal concentrations (MBCs) for all compounds were measured against standard strains of the bacteria , , and . All compounds exerted appreciable antimicrobial activity in the order of silver, zinc, copper, and gallium complexes.
将曲酸（HKA）与银（I）、铜（II）、锌（II）或镓（III）盐共结晶，得到三种 1D 配位聚合物和一种 0D 配合物，其中曲酸作为中性或阴离子末端或桥联配体存在。所有反应均通过球磨和手动研磨或通过浆料进行机械化学合成。所有固体均通过单晶和/或粉末 X 射线衍射进行了充分表征。由于曲酸是一种广泛用于化妆品的温和抗菌化合物，而金属阳离子具有抗菌性能，因此测试了它们的组合在潜在抗菌应用中的效果。所有化合物的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）均针对标准菌株、和进行了测量。所有化合物均表现出相当的抗菌活性，顺序为银、锌、铜和镓配合物。
