无载体姜黄素纳米粒子的制备、评价及抗氧化性能。

Fabrication, Evaluation, and Antioxidant Properties of Carrier-Free Curcumin Nanoparticles.

机构信息

Medical College, Guangxi University, Nanning 530004, China.

The Fourth People's Hospital of Nanning, Nanning 530023, China.

出版信息

Molecules. 2023 Jan 29;28(3):1298. doi: 10.3390/molecules28031298.

Curcumin (Cur), a natural hydrophobic polyphenolic compound, exhibits multiple beneficial biological activities. However, low water solubility and relative instability hinder its application in food fields. In this study, carrier-free curcumin nanoparticles (CFC NPs) were prepared by adding the DMSO solution of Cur into DI water under continuous rapid stirring. The morphology of CFC NPs was a spherical shape with a diameter of 65.25 ± 2.09 nm (PDI = 0.229 ± 0.107), and the loading capacity (LC) of CFC NPs was as high as 96.68 ± 0.03%. The thermal property and crystallinity of CFC NPs were investigated by XRD. Furthermore, the CFC NPs significantly accelerated the release of Cur in vitro owing to its improved water dispersibility. Importantly, CFC NPs displayed significantly improved DPPH radical scavenging activity. Overall, all these results suggested that CFC NPs would be a promising vehicle to widen the applications of Cur in food fields.

姜黄素（Cur）是一种天然疏水性多酚化合物，具有多种有益的生物活性。然而，低水溶性和相对不稳定性阻碍了其在食品领域的应用。在本研究中，通过在连续快速搅拌下将 DMSO 溶液中的姜黄素加入 DI 水中，制备了无载体姜黄素纳米粒子（CFC NPs）。CFC NPs 的形态为球形，直径为 65.25±2.09nm（PDI=0.229±0.107），载药量（LC）高达 96.68±0.03%。通过 XRD 研究了 CFC NPs 的热性能和结晶度。此外，由于其改善的水分散性，CFC NPs 显著加速了 Cur 的体外释放。重要的是，CFC NPs 显示出显著提高的 DPPH 自由基清除活性。总的来说，这些结果表明 CFC NPs 将是一种有前途的载体，可以拓宽姜黄素在食品领域的应用。