制备麦醇溶蛋白-羧甲基壳聚糖复合纳米颗粒以提高姜黄素的稳定性和抗氧化活性。
Fabrication of Gliadin-Carboxymethyl Chitosan Composite Nanoparticles to Improve the Stability and Antioxidant Activity of Curcumin.
作者信息
Zhang Xinyue, Mo Mengdie, Yu Haiqi, Yang Hua, Liu Xu, Xu Yaping, Zheng Xiaohui, Wei Jie, Yu Fei, Chen Xiaodong
机构信息
Medical College, Guangxi University, Nanning 530004, China.
Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Provincial University, Xiamen 361023, China.
出版信息
Molecules. 2025 May 30;30(11):2414. doi: 10.3390/molecules30112414.
The antisolvent precipitation method was employed to synthesize curcumin-loaded gliadin-carboxymethyl chitosan (CMCS) composite nanoparticles (GCC NPs). When the gliadin/CMCS weight ratio was 2:1, the GCC NPs with an ideal negative charge (-27.57 ± 1.07 mV) and the minimum particle size (184.13 ± 5.49 nm) were obtained. With the addition of CMCS, the encapsulation efficiency (EE) of Cur was markedly improved from 77.46 ± 1.54% to 93.88 ± 1.31%. Under various pH values and salt concentrations, the GCC NPs displayed excellent colloidal stability. Specifically, after encapsulation within the GCC NPs, the antioxidant activity of Cur was markedly improved. In ABTS and DPPH assays, the SC values of the GCC NPs were 4.98 ± 0.07 µg/mL and 9.86 ± 0.29 µg/mL, respectively. In summary, the GCC NPs would be an effective platform for the delivery of Cur in food and pharmaceutical preparations.
采用抗溶剂沉淀法合成了负载姜黄素的麦醇溶蛋白-羧甲基壳聚糖（CMCS）复合纳米粒子（GCC NPs）。当麦醇溶蛋白/CMCS的重量比为2:1时，可获得具有理想负电荷（-27.57±1.07 mV）且粒径最小（184.13±5.49 nm）的GCC NPs。随着CMCS的加入，姜黄素的包封率（EE）从77.46±1.54%显著提高到93.88±1.31%。在不同的pH值和盐浓度下，GCC NPs表现出优异的胶体稳定性。具体而言，在被包封于GCC NPs内后，姜黄素的抗氧化活性显著提高。在ABTS和DPPH测定中，GCC NPs的SC值分别为4.98±0.07 µg/mL和9.86±0.29 µg/mL。综上所述，GCC NPs将是食品和药物制剂中姜黄素递送有效的载体。
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