Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.
Department of Biophysics and Human Physiology, Medical University of Warsaw, 02-004 Warsaw, Poland.
Nutrients. 2023 Jan 23;15(3):595. doi: 10.3390/nu15030595.
Some endocrine disorders, previously considered benign, may be related to a poorer prognosis for patients with renal failure. Both low serum free triiodothyronine (fT3) and low total testosterone (TT) concentrations have been considered as predictors of death in dialysis patients, but the results of studies are inconsistent. In our study, we evaluated the relationships of the serum thyroid hormone levels and the total testosterone levels with survival in male dialysis patients.
Forty-eight male dialysis patients, 31 on hemodialysis (HD) and 17 on peritoneal dialysis (PD), aged 61.4 ± 10.0, 59.2 ± 12.2 years, respectively, were included in the study. Serum thyroid hormones and total testosterone were measured.
During the 12-month follow-up, nine all-cause deaths were recorded. The concentrations of fT3 were significantly lower in those who died than in the survivors ( = 0.001). We did not observe any statistically considerable differences between the group of men who died and the rest of the participants in terms of the total serum testosterone concentration ( = 0.350). Total testosterone positively correlated with fT3 (r = 0.463, = 0.009) in the HD group.
In the group of male dialysis patients, the serum concentration of fT3 had a better prognostic value in terms of survival than the total testosterone. A linear relationship between the fT3 levels and testosterone levels in men undergoing hemodialysis may confirm the hypothesis that some of the hormonal changes observed in chronic kidney disease (CKD) may have a common cause.
一些以前被认为是良性的内分泌疾病，可能与肾衰竭患者的预后较差有关。低血清游离三碘甲状腺原氨酸（fT3）和总睾酮（TT）浓度都被认为是透析患者死亡的预测因素，但研究结果不一致。在我们的研究中，我们评估了男性透析患者血清甲状腺激素水平和总睾酮水平与生存的关系。
48 名男性透析患者，31 名血液透析（HD），17 名腹膜透析（PD），年龄分别为 61.4 ± 10.0 岁和 59.2 ± 12.2 岁。测量血清甲状腺激素和总睾酮。
在 12 个月的随访中，记录了 9 例全因死亡。死亡者的 fT3 浓度明显低于幸存者（ = 0.001）。我们没有观察到死亡组与其余参与者在总血清睾酮浓度方面有任何统计学上的显著差异（ = 0.350）。在 HD 组中，总睾酮与 fT3 呈正相关（r = 0.463， = 0.009）。
在男性透析患者中，fT3 血清浓度在生存方面比总睾酮具有更好的预后价值。接受血液透析的男性中 fT3 水平与睾酮水平之间的线性关系可能证实了这样一种假设，即慢性肾脏病（CKD）中观察到的一些激素变化可能有一个共同的原因。
