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Wikim0066 通过调控 MMP 对 UVB 照射体外和体内模型的皮肤起保护作用。

Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model.

机构信息

MEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of Korea.

出版信息

Nutrients. 2023 Feb 1;15(3):726. doi: 10.3390/nu15030726.

DOI:10.3390/nu15030726

PMID:36771432

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919521/

Abstract

Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of matrix metalloproteinases (MMP). We confirmed the effects of wikim0066 (wikim0066) on UVB-irradiated Hs68 cells and HR-1 hairless mice cells. wikim0066 restored the production of type I procollagen by regulating the expression of MMP-1 and -3, MAPK, AP-1, and NF-κB in UVB-irradiated Hs68 cells and HR-1 mice. Oral administration of wikim0066 alleviates wrinkle formation, epidermal thickness, and TEWL in UVB-irradiated HR-1 hairless mice. These results indicated that wikim0066 has the potential to prevent UVB-induced wrinkle formation.

摘要

紫外线（UV）B 照射会导致皱纹形成、胶原蛋白纤维断裂和经表皮水分流失（TEWL）。UVB 照射会诱导丝裂原活化蛋白激酶（MAPK）、激活蛋白 1（AP-1）和核因子 kappa B（NF-κB）的表达，从而影响基质金属蛋白酶（MMP）的表达。我们证实了 wikim0066（wikim0066）对 UVB 照射的 Hs68 细胞和 HR-1 无毛小鼠细胞的影响。wikim0066 通过调节 MMP-1 和 -3、MAPK、AP-1 和 NF-κB 的表达，恢复了 I 型前胶原蛋白的产生，从而恢复了 UVB 照射的 Hs68 细胞和 HR-1 小鼠的 I 型前胶原蛋白的产生。口服 wikim0066 可减轻 UVB 照射的 HR-1 无毛小鼠的皱纹形成、表皮厚度和 TEWL。这些结果表明 wikim0066 具有预防 UVB 诱导的皱纹形成的潜力。