• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MG5368和MG989调节紫外线诱导的HaCaT细胞和无毛小鼠模型中的皮肤健康。

MG5368 and MG989 Regulates Skin Health in UVB-Induced HaCaT Cells and Hairless Mice Model.

作者信息

Park Jeong-Yong, Lee Ji Yeon, Hong Seonghwa, Heo Huijin, Lee Hana, Kim Yong Gyeong, Kim Byoung-Kook, Choi Soo-Im, Lee Junsoo

机构信息

Mediogen, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of Korea.

Department of Food Science and Biotechnology, Chungbuk National University, Cheongju-si 28644, Republic of Korea.

出版信息

Nutrients. 2024 Nov 27;16(23):4083. doi: 10.3390/nu16234083.

DOI:10.3390/nu16234083
PMID:39683478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643855/
Abstract

BACKGROUND

Photoaging, induced by chronic ultraviolet B (UVB) exposure, results in the degradation of extracellular matrix (ECM) components, leading to skin roughness, wrinkle formation, and reduced elasticity. Recent studies have explored probiotics as potential inhibitors of extrinsic aging, primarily through mechanisms that protect the skin barrier and reduce collagen breakdown.

METHODS

This study investigates the anti-photoaging effects of MG5368 ( MG5368) and MG989 ( MG989) in UVB-exposed keratinocytes and an SKH-1 hairless mice model.

RESULTS

Both strains demonstrated significant efficacy in preserving collagen through the inhibition of activating protein-1 (AP-1) and reducing the expression of matrix metalloproteinase (MMP)-1 and MMP-3. Additionally, both strains restored COL1A1 protein expressions, thereby enhancing collagen synthesis and ECM stability. Enhanced skin elasticity was observed, attributed to restored levels of hyaluronic acid and hyaluronan synthase 2 (HAS2) protein expressions.

CONCLUSIONS

These findings suggest that MG5368 and MG989 may serve as promising probiotic-based agents for anti-photoaging applications.

摘要

背景

长期暴露于紫外线B（UVB）引起的光老化会导致细胞外基质（ECM）成分降解，从而导致皮肤粗糙、皱纹形成和弹性降低。最近的研究探索了益生菌作为外在老化的潜在抑制剂，主要通过保护皮肤屏障和减少胶原蛋白分解的机制。

方法

本研究调查了MG5368和MG989在UVB照射的角质形成细胞和SKH-1无毛小鼠模型中的抗光老化作用。

结果

两种菌株均通过抑制活化蛋白-1（AP-1）和降低基质金属蛋白酶（MMP）-1和MMP-3的表达，在保存胶原蛋白方面显示出显著功效。此外，两种菌株均恢复了COL1A1蛋白表达，从而增强了胶原蛋白合成和ECM稳定性。观察到皮肤弹性增强，这归因于透明质酸和透明质酸合酶2（HAS2）蛋白表达水平的恢复。

结论

这些发现表明，MG5368和MG989可能作为有前景的基于益生菌的抗光老化应用药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/7cd8fd876914/nutrients-16-04083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/8203090bd7f3/nutrients-16-04083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/79e8ccdce420/nutrients-16-04083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/0a5f6262b38e/nutrients-16-04083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/60b62f6f5559/nutrients-16-04083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/8bc5c3d829c2/nutrients-16-04083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/7cd8fd876914/nutrients-16-04083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/8203090bd7f3/nutrients-16-04083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/79e8ccdce420/nutrients-16-04083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/0a5f6262b38e/nutrients-16-04083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/60b62f6f5559/nutrients-16-04083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/8bc5c3d829c2/nutrients-16-04083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c985/11643855/7cd8fd876914/nutrients-16-04083-g006.jpg

相似文献

1
MG5368 and MG989 Regulates Skin Health in UVB-Induced HaCaT Cells and Hairless Mice Model.MG5368和MG989调节紫外线诱导的HaCaT细胞和无毛小鼠模型中的皮肤健康。
Nutrients. 2024 Nov 27;16(23):4083. doi: 10.3390/nu16234083.
2
Hawthorn Polyphenol Extract Inhibits UVB-Induced Skin Photoaging by Regulating MMP Expression and Type I Procollagen Production in Mice.山楂多酚提取物通过调节 MMP 表达和 I 型前胶原产生抑制 UVB 诱导的皮肤光老化。
J Agric Food Chem. 2018 Aug 15;66(32):8537-8546. doi: 10.1021/acs.jafc.8b02785. Epub 2018 Jul 31.
3
Oral administration of Lactobacillus plantarum HY7714 protects hairless mouse against ultraviolet B-induced photoaging.口服植物乳杆菌HY7714可保护无毛小鼠免受紫外线B诱导的光老化。
J Microbiol Biotechnol. 2014 Nov 28;24(11):1583-91. doi: 10.4014/jmb.1406.06038.
4
Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice.亚油酸可预防无毛小鼠 UVB 诱导的皮肤光老化。
Nutrients. 2019 Dec 4;11(12):2948. doi: 10.3390/nu11122948.
5
N-benzyl-N-methyldecane-1-amine derived from garlic ameliorates UVB-induced photoaging in HaCaT cells and SKH-1 hairless mice.源自大蒜的N-苄基-N-甲基癸烷-1-胺可改善中波紫外线诱导的HaCaT细胞和SKH-1无毛小鼠的光老化。
Sci Rep. 2025 Feb 26;15(1):6979. doi: 10.1038/s41598-025-88634-9.
6
Effects of Galla chinensis extracts on UVB-irradiated MMP-1 production in hairless mice.五倍子提取物对紫外线B照射的无毛小鼠基质金属蛋白酶-1产生的影响。
J Nat Med. 2015 Jan;69(1):22-34. doi: 10.1007/s11418-014-0856-6. Epub 2014 Sep 17.
7
Photoprotective activities of Capsosiphon fulvescens in UVB-induced SKH-1 mice and human keratinocytes.金顶侧耳对 UVB 诱导的 SKH-1 小鼠和人角质形成细胞的光保护活性。
J Food Sci. 2024 Aug;89(8):5150-5163. doi: 10.1111/1750-3841.17246. Epub 2024 Jul 11.
8
Fermentation of Blackberry with JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.黑莓经 JBMI F5 发酵后，通过调控 MAPK/NF-κB 信号通路增强对 UVB 诱导的人包皮成纤维细胞和无毛小鼠光老化的保护作用。
Nutrients. 2019 Oct 11;11(10):2429. doi: 10.3390/nu11102429.
9
Oral administration of Aloe vera gel powder prevents UVB-induced decrease in skin elasticity via suppression of overexpression of MMPs in hairless mice.口服芦荟凝胶粉可通过抑制无毛小鼠中基质金属蛋白酶的过度表达来预防紫外线B诱导的皮肤弹性下降。
Biosci Biotechnol Biochem. 2016 Jul;80(7):1416-24. doi: 10.1080/09168451.2016.1156480. Epub 2016 Apr 4.
10
Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice.小麦胚芽油（WEO）通过促进人角质形成细胞和无毛小鼠胶原合成来减轻 UVB 诱导的光老化。
Nutrients. 2020 Jan 22;12(2):300. doi: 10.3390/nu12020300.

引用本文的文献

1
The Expanding Role of Probiotics in Human Health.益生菌在人类健康中不断扩大的作用。
Nutrients. 2025 Mar 24;17(7):1116. doi: 10.3390/nu17071116.

本文引用的文献

1
The structural characterization and UV-protective properties of an exopolysaccharide from a isolate.一种分离菌株胞外多糖的结构表征及紫外线防护特性
Front Pharmacol. 2024 Aug 9;15:1434136. doi: 10.3389/fphar.2024.1434136. eCollection 2024.
2
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study.由于内在老化导致的人类皮肤成分的变化：组织学和形态计量学研究。
Histochem Cell Biol. 2024 Oct;162(4):259-271. doi: 10.1007/s00418-024-02305-w. Epub 2024 Jul 2.
3
Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3.
表皮角质形成细胞通过细胞外分泌的透明质酸酶 1 和透明质酸合酶 3 调节透明质酸代谢。
J Biol Chem. 2024 Jul;300(7):107449. doi: 10.1016/j.jbc.2024.107449. Epub 2024 Jun 4.
4
Protective effect of mixture of and against ultraviolet B-induced photodamage in human fibroblast and hairless mouse.[具体物质1]与[具体物质2]的混合物对紫外线B诱导的人成纤维细胞和无毛小鼠光损伤的保护作用。
Food Sci Biotechnol. 2023 Nov 10;33(7):1715-1725. doi: 10.1007/s10068-023-01462-3. eCollection 2024 Jun.
5
Antioxidants in Photoaging: From Molecular Insights to Clinical Applications.光老化中的抗氧化剂：从分子见解到临床应用。
Int J Mol Sci. 2024 Feb 18;25(4):2403. doi: 10.3390/ijms25042403.
6
Reviewing the Regulators of COL1A1.探讨 COL1A1 的调控因子。
Int J Mol Sci. 2023 Jun 11;24(12):10004. doi: 10.3390/ijms241210004.
7
Detection of skin wrinkles and quantification of roughness using a novel image processing technique from a dermatoscope device.利用皮肤镜设备的新型图像处理技术检测皮肤皱纹和粗糙度定量评估。
Skin Res Technol. 2023 Jun;29(6):e13335. doi: 10.1111/srt.13335.
8
Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474.TNFα/IFNγ 诱导的 HaCaT 角质细胞中的抗炎反应及 MG4644、MG4693 和 MG5474 的益生菌特性。
J Microbiol Biotechnol. 2023 Aug 28;33(8):1039-1049. doi: 10.4014/jmb.2301.01028. Epub 2023 May 5.
9
Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model.Wikim0066 通过调控 MMP 对 UVB 照射体外和体内模型的皮肤起保护作用。
Nutrients. 2023 Feb 1;15(3):726. doi: 10.3390/nu15030726.
10
Effects of probiotics supplementation on skin photoaging and skin barrier function: A systematic review and meta-analysis.补充益生菌对皮肤光老化和皮肤屏障功能的影响：一项系统评价和荟萃分析。
Photodermatol Photoimmunol Photomed. 2023 Mar;39(2):122-131. doi: 10.1111/phpp.12861. Epub 2023 Jan 11.