MG5368和MG989调节紫外线诱导的HaCaT细胞和无毛小鼠模型中的皮肤健康。
MG5368 and MG989 Regulates Skin Health in UVB-Induced HaCaT Cells and Hairless Mice Model.
作者信息
Park Jeong-Yong, Lee Ji Yeon, Hong Seonghwa, Heo Huijin, Lee Hana, Kim Yong Gyeong, Kim Byoung-Kook, Choi Soo-Im, Lee Junsoo
机构信息
Mediogen, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of Korea.
Department of Food Science and Biotechnology, Chungbuk National University, Cheongju-si 28644, Republic of Korea.
出版信息
Nutrients. 2024 Nov 27;16(23):4083. doi: 10.3390/nu16234083.
BACKGROUND
Photoaging, induced by chronic ultraviolet B (UVB) exposure, results in the degradation of extracellular matrix (ECM) components, leading to skin roughness, wrinkle formation, and reduced elasticity. Recent studies have explored probiotics as potential inhibitors of extrinsic aging, primarily through mechanisms that protect the skin barrier and reduce collagen breakdown.
METHODS
This study investigates the anti-photoaging effects of MG5368 ( MG5368) and MG989 ( MG989) in UVB-exposed keratinocytes and an SKH-1 hairless mice model.
RESULTS
Both strains demonstrated significant efficacy in preserving collagen through the inhibition of activating protein-1 (AP-1) and reducing the expression of matrix metalloproteinase (MMP)-1 and MMP-3. Additionally, both strains restored COL1A1 protein expressions, thereby enhancing collagen synthesis and ECM stability. Enhanced skin elasticity was observed, attributed to restored levels of hyaluronic acid and hyaluronan synthase 2 (HAS2) protein expressions.
CONCLUSIONS
These findings suggest that MG5368 and MG989 may serve as promising probiotic-based agents for anti-photoaging applications.
背景
长期暴露于紫外线B（UVB）引起的光老化会导致细胞外基质（ECM）成分降解，从而导致皮肤粗糙、皱纹形成和弹性降低。最近的研究探索了益生菌作为外在老化的潜在抑制剂，主要通过保护皮肤屏障和减少胶原蛋白分解的机制。
方法
本研究调查了MG5368和MG989在UVB照射的角质形成细胞和SKH-1无毛小鼠模型中的抗光老化作用。
结果
两种菌株均通过抑制活化蛋白-1（AP-1）和降低基质金属蛋白酶（MMP）-1和MMP-3的表达，在保存胶原蛋白方面显示出显著功效。此外，两种菌株均恢复了COL1A1蛋白表达，从而增强了胶原蛋白合成和ECM稳定性。观察到皮肤弹性增强，这归因于透明质酸和透明质酸合酶2（HAS2）蛋白表达水平的恢复。
结论
这些发现表明，MG5368和MG989可能作为有前景的基于益生菌的抗光老化应用药物。
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