氯丙嗪对人体药物吸收及胃排空的影响。

Effect of chlorpromazine on drug absorption and gastric emptying in man.

作者信息

Petring O U, Adelhøj B, Ibsen M, Poulsen H E

机构信息

Department of Anaesthesiology, Kommunehospitalet, Copenhagen, Denmark.

出版信息

Can J Anaesth. 1987 Nov;34(6):563-5. doi: 10.1007/BF03010511.

DOI:10.1007/BF03010511

PMID:3677280

Abstract

In a double-blind study the effect of a single IV dose (25 mg) of chlorpromazine on gastric emptying, as determined by the rate of paracetamol absorption, was measured in seven healthy volunteers. Each volunteer acted as his/her own control. There was no significant difference between the maximum paracetamol concentration, the time to reach the plasma maximum concentration, and the area under the plasma concentration time curve from 0-120 minutes on the two occasions, indicating unchanged gastric emptying after administration of chlorpromazine.

摘要

在一项双盲研究中，对7名健康志愿者测定了静脉注射单剂量（25毫克）氯丙嗪对胃排空的影响，胃排空通过对乙酰氨基酚的吸收速率来确定。每位志愿者均作为自身对照。两次测量时，对乙酰氨基酚的最大浓度、达到血浆最大浓度的时间以及0至120分钟血浆浓度时间曲线下的面积均无显著差异，表明注射氯丙嗪后胃排空未发生改变。