Kasai H, Nishimura S, Kurokawa Y, Hayashi Y
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
Carcinogenesis. 1987 Dec;8(12):1959-61. doi: 10.1093/carcin/8.12.1959.
Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.
给大鼠口服肾脏致癌物溴酸钾（KBrO₃）后，观察到肾脏DNA中的8-羟基脱氧鸟苷（8-OH-dG）显著增加。在非靶组织肝脏中，8-OH-dG的增加并不显著。非致癌性氧化剂次氯酸钠（NaClO）和亚氯酸钠（NaClO₂）对肾脏DNA中8-OH-dG的形成没有影响。这些结果表明，组织DNA中8-OH-dG的形成与KBrO₃致癌作用密切相关。
