Environmental Biology, Centre for Environmental Sciences, Hasselt University, B-3590, Diepenbeek, Belgium.
Environmental Biology, Centre for Environmental Sciences, Hasselt University, B-3590, Diepenbeek, Belgium.
Free Radic Biol Med. 2023 Apr;199:81-96. doi: 10.1016/j.freeradbiomed.2023.02.010. Epub 2023 Feb 10.
Cadmium (Cd) is one of the most toxic compounds released into our environment and is harmful to human health, urging the need to remediate Cd-polluted soils. To this end, it is important to increase our insight into the molecular mechanisms underlying Cd stress responses in plants, ultimately leading to acclimation, and to develop novel strategies for economic validation of these soils. Albeit its non-redox-active nature, Cd causes a cellular oxidative challenge, which is a crucial determinant in the onset of diverse signalling cascades required for long-term acclimation and survival of Cd-exposed plants. Although it is well known that Cd affects reactive oxygen species (ROS) production and scavenging, the contribution of individual organelles to Cd-induced oxidative stress responses is less well studied. Here, we provide an overview of the current information on Cd-induced organellar responses with special attention to redox biology. We propose that an integration of organellar ROS signals with other signalling pathways is essential to finetune plant acclimation to Cd stress.
镉 (Cd) 是释放到环境中的最有毒化合物之一，对人类健康有害，因此需要修复镉污染的土壤。为此，重要的是要提高我们对植物中镉胁迫反应的分子机制的认识，最终实现适应，并开发出经济验证这些土壤的新策略。尽管镉没有氧化还原活性，但它会引起细胞氧化应激，这是引发镉暴露植物长期适应和生存所需的各种信号级联反应的关键决定因素。虽然众所周知，镉会影响活性氧 (ROS) 的产生和清除，但个别细胞器对镉诱导的氧化应激反应的贡献研究得还不够充分。在这里，我们提供了一个关于镉诱导的细胞器反应的最新信息概述，特别关注氧化还原生物学。我们提出，细胞器 ROS 信号与其他信号通路的整合对于植物适应镉胁迫至关重要。
