Zhonghua Yi Xue Za Zhi. 2023 Feb 14;103(6):387-403. doi: 10.3760/cma.j.cn112137-20220907-01895.
Young breast cancer patients are associated with high-risk clinicopathological features and poor prognosis, leading to unique medical and psychosocial needs and calling for special attention in clinical practice. In recent years, the incidence of young breast cancer has gradually increased worldwide, and several international committees have formed some consensuses on young breast cancer management. In China, there is a higher proportion of young breast cancer patients with younger age of onset and different clinical problems, lacking clear evidence-based medicine and guidelines. Based on the characteristics of young breast cancer and present situation of diagnosis and treatment in China, more than 100 experts from multiple specialities including surgery, internal medicine, radiotherapy, gynecology and reproduction had a deep discussion around the hot topics in young breast cancer, involving germline BRCA1/2 gene mutation, chemotherapy, endocrine therapy, fertility preservation and gynecological conditions, and formulated the 'Expert consensus on the diagnosis and treatment of young breast cancer in China (2022 Edition)'. This consensus is made according to the progress of clinical research worldwide and combined with the clinical practice in China, with the aims of standardizing and optimizing the diagnosis and treatment of young breast cancer in China, promoting the development of relevant clinical research, and further improving the prognosis and quality of life of young breast cancer patients.
年轻乳腺癌患者具有高危临床病理特征且预后较差,导致其有独特的医疗和心理社会需求,在临床实践中需要特别关注。近年来,年轻乳腺癌的发病率在全球范围内逐渐上升,多个国际委员会已就年轻乳腺癌的管理形成了一些共识。在中国,年轻乳腺癌患者的发病年龄更小且存在不同临床问题的比例更高,缺乏明确的循证医学依据和指南。基于年轻乳腺癌的特点及中国的诊治现状,来自外科、内科、放疗、妇科及生殖等多个专业的100余位专家围绕年轻乳腺癌的热点问题进行了深入讨论,内容涉及胚系BRCA1/2基因突变、化疗、内分泌治疗、生育力保护及妇科情况等,并制定了《中国年轻乳腺癌诊疗专家共识(2022年版)》。本共识依据全球临床研究进展并结合中国临床实践制定,旨在规范和优化中国年轻乳腺癌的诊治,推动相关临床研究发展,进一步改善年轻乳腺癌患者的预后和生活质量。