Department of Obstetrics and Gynecology, Universitas Padjadjaran, Bandung, West Java, Indonesia.
Department of Anatomical Pathology, Universitas Padjadjaran, Bandung, West Java, Indonesia.
Am J Case Rep. 2023 Feb 13;24:e938680. doi: 10.12659/AJCR.938680.
BACKGROUND Ovarian cancer is the leading cause of death in women with gynecological cancers. Ovarian Brenner tumor (BT) is an extremely rare type of epithelial ovarian cancer that accounts for about 1-3% of all ovarian cancers. Herein, we report a rare case of ruptured malignant ovarian Brenner tumor. CASE REPORT A 39-year-old P0A0 woman came to the Emergency Department (ED) with abdominal pain and tenderness. Perforated appendicitis was initially suspected and an emergency laparotomy was performed by the General Surgery Department. Then, a 25×20×15 cm grayish cystic mass originating from the right adnexa was found. We consulted intraoperatively with the Gynecology Oncology Department and decided to perform complete surgical staging. Histopathological examination confirmed the diagnosis of malignant Brenner tumor (MBT). The patient was then given adjuvant chemotherapy with a paclitaxel carboplatin regimen. In this case report, we present our case along with a review of the current literature regarding the diagnosis and therapy of malignant Brenner tumor. CONCLUSIONS Ovarian MBT is an extremely rare ovarian cancer. Diagnosing MBT can be challenging as there are no clinical, laboratory, or imaging features typical for it. Surgery is the mainstay treatment in MBT cases. The role of adjuvant chemotherapy in MBT is still being debated.
卵巢癌是妇科癌症患者死亡的主要原因。卵巢 Brenner 肿瘤（BT）是一种极为罕见的上皮性卵巢癌，约占所有卵巢癌的 1-3%。本文报告一例罕见的破裂性恶性卵巢 Brenner 肿瘤。
一名 39 岁的 P0A0 女性因腹痛和压痛就诊于急诊科。最初怀疑为穿孔性阑尾炎，并由普外科行急诊剖腹手术。随后，在右侧附件处发现一个 25×20×15 cm 的灰白色囊性肿块。我们术中咨询了妇科肿瘤科，并决定行全面的手术分期。组织病理学检查证实了恶性 Brenner 肿瘤（MBT）的诊断。随后，患者接受了紫杉醇卡铂方案的辅助化疗。在本病例报告中，我们介绍了我们的病例，并回顾了目前关于恶性 Brenner 肿瘤的诊断和治疗的文献。
卵巢 MBT 是一种极为罕见的卵巢癌。由于没有特定的临床、实验室或影像学特征，因此诊断 MBT 具有挑战性。手术是 MBT 病例的主要治疗方法。辅助化疗在 MBT 中的作用仍存在争议。
