衰老大鼠体内的谷胱甘肽与脂质过氧化作用
Glutathione and lipid peroxidation in the aging rat.
作者信息
Farooqui M Y, Day W W, Zamorano D M
机构信息
Department of Biology, Pan American University, Edinburg, TX 78539.
出版信息
Comp Biochem Physiol B. 1987;88(1):177-80. doi: 10.1016/0305-0491(87)90097-6.
PMID:3677596
Abstract
- Tissue extracts were prepared from liver, kidney, heart, brain, lung and spleen of male Sprague-Dawley rats of different ages (1-36 months); each of the extracts was analyzed for reduced glutathione (GSH) and lipid peroxides. 2. At all ages the GSH content in the liver was 3-10 times higher than that in other tissues. 3. In the old (36 months) rat the GSH content of all the tissues studied were lower (35-60%) than that in 2.5 month old rat. 4. The lipid peroxides levels increased by age in all tissues studied. 5. These findings indicate that general characteristics of aging tissue may include a decrease in GSH content and increase in lipid peroxides showing a decrease in reducing potential in senescence.
摘要
- 从不同年龄（1至36个月）的雄性斯普拉格-道利大鼠的肝脏、肾脏、心脏、大脑、肺和脾脏制备组织提取物；对每种提取物进行还原型谷胱甘肽（GSH）和脂质过氧化物分析。2. 在所有年龄段，肝脏中的GSH含量比其他组织高3至10倍。3. 在老年（36个月）大鼠中，所有研究组织的GSH含量均低于2.5个月龄大鼠（低35%至60%）。4. 在所有研究组织中，脂质过氧化物水平随年龄增长而增加。5. 这些发现表明，衰老组织的一般特征可能包括GSH含量降低和脂质过氧化物增加，显示衰老过程中还原电位降低。
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