狒狒红细胞膜蛋白的发育变化

Developmental changes in membrane proteins from baboon erythrocytes.

Lee J C, Kuehl T J, Roodman G D

Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760.

Comp Biochem Physiol B. 1987;88(1):223-6.

Abstract

Total membrane proteins from freshly isolated erythrocytes of fetal, newborn, and adult baboons were analyzed by electrophoresis. 2. The electrophoretic patterns of proteins from newborns and adults were similar but those from adults and fetuses were different. 3. Four proteins, P165, P155, P75, and P49, with approximate mol. wts of 165,000, 155,000, 75,000, and 49,000, respectively, were present in adult but not in fetal samples. 4. P155 and P49, were glycoproteins; P49 was a cell-surface protein. 5. The membrane protein characteristics of the adult erythrocyte differ from those of the fetal erythrocytes and at least four polypeptides are associated with development of the adult phenotype.

摘要

采用电泳法分析了来自胎儿、新生儿和成年狒狒新鲜分离红细胞的总膜蛋白。2. 新生儿和成年人蛋白质的电泳图谱相似，但成年人和胎儿的电泳图谱不同。3. 四种蛋白质，P165、P155、P75和P49，其分子量分别约为165,000、155,000、75,000和49,000，存在于成年样本中，但不存在于胎儿样本中。4. P155和P49是糖蛋白；P49是一种细胞表面蛋白。5. 成年红细胞的膜蛋白特征与胎儿红细胞不同，至少有四种多肽与成年表型的发育有关。