Zhang Meng, He Yanchao, Jie Zhijun
Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Center of Community-Based Health Research, Fudan University, Shanghai 200240, China.
J Transl Int Med. 2022 Sep 24;10(3):227-235. doi: 10.2478/jtim-2022-0026. eCollection 2022 Sep.
The pandemic coronavirus disease 2019 (COVID-19) has rapidly spread to all countries worldwide. The emergence of its variants has exacerbated this problem. To date, many variants have been identified across the viral genome; the variants of concern are the focus of attention due to their higher transmissibility and resistance to vaccines, especially the delta variant. The delta variant has become the dominant severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) variant worldwide, causing severe panic as it is highly infectious. A better understanding of these variants may help in the development of possible treatments and save more lives. In this study, we summarize the characteristics of the variants of concern. More importantly, we summarize the results of previous studies on the delta variant. The delta variant has a high transmissibility rate and increases the risk of hospitalization and death. However, it is partially sensitive to vaccines. In addition, nonpharmaceutical interventions are valuable during epidemics. These interventions can be used against the delta variant, but managing this variant should still be taken seriously.
2019年大流行性冠状病毒病（COVID-19）已迅速蔓延至全球所有国家。其变异株的出现加剧了这一问题。迄今为止，已在病毒基因组中鉴定出许多变异株；值得关注的变异株因其更高的传播性和对疫苗的抗性而成为关注焦点，尤其是德尔塔变异株。德尔塔变异株已成为全球范围内严重急性呼吸综合征新型冠状病毒（SARS-CoV-2）的主要变异株，因其具有高度传染性而引发了严重恐慌。更好地了解这些变异株可能有助于开发可能的治疗方法并挽救更多生命。在本研究中，我们总结了值得关注的变异株的特征。更重要的是，我们总结了先前关于德尔塔变异株的研究结果。德尔塔变异株具有高传播率，增加了住院和死亡风险。然而，它对疫苗部分敏感。此外，非药物干预在疫情期间很有价值。这些干预措施可用于应对德尔塔变异株，但仍应认真对待对该变异株的管控。
