Fei Sijia, Feng Xinyuan, Luo Jingyi, Guo Lixin, Pan Qi
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Graduate School of Peking Union Medical College, Beijing 100730, China.
J Transl Int Med. 2022 Sep 24;10(3):207-218. doi: 10.2478/jtim-2022-0020. eCollection 2022 Sep.
The coronavirus disease 2019 (COVID-19) pandemic has brought severe challenges to global public health. Many studies have shown that obesity plays a vital role in the occurrence and development of COVID-19. Obesity exacerbates COVID-19, leading to increased intensive care unit hospitalization rate, high demand for invasive mechanical ventilation, and high mortality. The mechanisms of interaction between obesity and COVID-19 involve inflammation, immune response, changes in pulmonary dynamics, disruptions of receptor ligands, and dysfunction of endothelial cells. Therefore, for obese patients with COVID-19, the degree of obesity and related comorbidities should be evaluated. Treatment methods such as administration of anticoagulants and anti-inflammatory drugs like glucocorticoids and airway management should be actively initiated. We should also pay attention to long-term prognosis and vaccine immunity and actively address the physical and psychological problems caused by longterm staying-at-home during the pandemic. The present study summarized the research to investigate the role of obesity in the incidence and progression of COVID-19 and the psychosocial impact and treatment options for obese patients with COVID-19, to guide the understanding and management of the disease.
2019冠状病毒病（COVID-19）大流行给全球公共卫生带来了严峻挑战。许多研究表明，肥胖在COVID-19的发生和发展中起着至关重要的作用。肥胖会加重COVID-19病情，导致重症监护病房住院率增加、有创机械通气需求高以及死亡率高。肥胖与COVID-19之间的相互作用机制涉及炎症、免疫反应、肺动力学变化、受体配体破坏以及内皮细胞功能障碍。因此，对于患有COVID-19的肥胖患者，应评估肥胖程度和相关合并症。应积极启动抗凝治疗以及使用糖皮质激素等抗炎药物和气道管理等治疗方法。我们还应关注长期预后和疫苗免疫，并积极解决疫情期间长期居家造成的身心问题。本研究总结了相关研究，以探讨肥胖在COVID-19发病和进展中的作用以及COVID-19肥胖患者的社会心理影响和治疗选择，以指导对该疾病的认识和管理。
