Zhuo Xiaohuang, Zhou Yongzhao, Liu Ling
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Precision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2023 Jan 27;13:965939. doi: 10.3389/fneur.2022.965939. eCollection 2022.
() is an extremely rare pathogenic bacterium, which causes serious infections in patients with primary immunodeficiency or tumors, and it is often misdiagnosed. has rarely been known to cause a neurologic infection. We describe the first case of acute bacterial encephalitis associated with infection in a man with recurrent nasopharyngeal carcinoma, which was successfully cured by antibiotics. The patient initially presented with recurrent episodes of fever and later showed impaired consciousness but these symptoms were alleviated with antibiotic therapy including cefoperazone/sulbactam. This study highlights that rapid and accurate pathogen detection metagenomic next-generation sequencing and early use of appropriate antibiotics can improve the prognosis of patients with suspected neurologic infection. Early treatment for underlying primary diseases can also significantly improve the outcomes of patients.
()是一种极其罕见的致病细菌,可在原发性免疫缺陷或肿瘤患者中引起严重感染,且常被误诊。很少有人知道它会引起神经系统感染。我们描述了首例与复发性鼻咽癌男性患者感染()相关的急性细菌性脑炎病例,该患者通过抗生素成功治愈。患者最初表现为反复发热,随后出现意识障碍,但这些症状通过包括头孢哌酮/舒巴坦在内的抗生素治疗得到缓解。本研究强调,通过宏基因组下一代测序进行快速准确的病原体检测以及早期使用适当的抗生素可改善疑似神经系统()感染患者的预后。对潜在原发性疾病的早期治疗也可显著改善患者的治疗结果。