Gao Hongguang, Li Tian, Feng Li, Zhang Shu
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Front Med (Lausanne). 2021 Dec 24;8:761924. doi: 10.3389/fmed.2021.761924. eCollection 2021.
is a rarely encountered bacterium in clinical practice. It is a rare gram-negative rod-shaped bacterium associated with lung and urinary tract infections, but never found in cerebrospinal fluid. This paper reports a case of an adult patient infected by via an unknown route of infection causing a severe intracranial infection. was detected by culture and Metagenomic next generation sequencing in CSF. Early identification of this strain and treatment with sensitive antibiotics is necessary to reduce morbidity and mortality. A 24-year-old male was admitted to a West China Hospital because of headache and vomiting for 2 months. Symptom features included acute onset and long duration of illness. Notably, headache and vomiting were the primary neurological symptoms. Routine cerebrospinal fluid culture failed to identify the bacterium; however, bacterium was detected via second-generation sequencing techniques. was found to be a multi-drug resistant organism, hence, treatment with ceftriaxone, a commonly used drug for intracranial infections was ineffective. This strain eventually caused severe intracranial infection resulting in the death of the patient. In summary, this study comprehensively describes a case of an adult patient infected by and discusses its early identification as well as application of sensitive antibiotics in the emergency setting.
是临床实践中很少遇到的一种细菌。它是一种罕见的革兰氏阴性杆状细菌，与肺部和尿路感染有关，但从未在脑脊液中发现。本文报告了一例成年患者通过未知感染途径感染 导致严重颅内感染的病例。通过脑脊液培养和宏基因组下一代测序检测到了 。早期识别该菌株并用敏感抗生素进行治疗对于降低发病率和死亡率是必要的。一名24岁男性因头痛和呕吐2个月入住华西医院。症状特征包括起病急和病程长。值得注意的是，头痛和呕吐是主要的神经系统症状。常规脑脊液培养未能鉴定出该细菌；然而，通过第二代测序技术检测到了 细菌。发现 是一种多重耐药菌，因此，使用颅内感染常用药物头孢曲松治疗无效。该菌株最终导致严重颅内感染，致使患者死亡。总之，本研究全面描述了一例成年患者感染 的病例，并讨论了其早期识别以及在紧急情况下敏感抗生素的应用。
