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本文引用的文献

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Safety of local anesthetics.局部麻醉药的安全性。
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2
Local Anesthetic Systemic Toxicity: A Narrative Literature Review and Clinical Update on Prevention, Diagnosis, and Management.局部麻醉药全身毒性:预防、诊断和管理的叙述性文献复习和临床更新。
Plast Reconstr Surg. 2019 Sep;144(3):783-795. doi: 10.1097/PRS.0000000000005989.
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Tumescent Liposuction without Lidocaine.无利多卡因的肿胀吸脂术。
Plast Reconstr Surg Glob Open. 2016 Aug 9;4(8):e829. doi: 10.1097/GOX.0000000000000830. eCollection 2016 Aug.
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Cytotoxicity of local anesthetics on human mesenchymal stem cells in vitro.局部麻醉药对人骨髓间充质干细胞的体外细胞毒性。
Arthroscopy. 2013 Oct;29(10):1676-84. doi: 10.1016/j.arthro.2013.06.018. Epub 2013 Aug 29.
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Cytotoxicity of local anesthetics on human mesenchymal stem cells.局麻药对人骨髓间充质干细胞的细胞毒性。
J Bone Joint Surg Am. 2013 Jan 16;95(2):132-7. doi: 10.2106/JBJS.K.01291.
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Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine.人软骨细胞接触利多卡因、布比卡因和罗哌卡因后的细胞凋亡和线粒体功能障碍。
J Bone Joint Surg Am. 2010 Mar;92(3):609-18. doi: 10.2106/JBJS.H.01847.
7
Mechanisms influencing the vasoactive effects of lidocaine in human skin.利多卡因对人体皮肤血管活性作用的影响机制。
Anaesthesia. 2007 Feb;62(2):146-50. doi: 10.1111/j.1365-2044.2006.04901.x.
8
Bupivacaine, levobupivacaine and ropivacaine: are they clinically different?布比卡因、左旋布比卡因和罗哌卡因:它们在临床上有差异吗?
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抽脂术后使用含罗哌卡因的肿胀液减轻疼痛

Pain Reduction Using Ropivacaine in Tumescent Solution following Lipoaspiration.

作者信息

Mantripragada Koushik, Yerke Hansen Payton, Vazquez Oscar Adrian, Pires Giovanna, Becker Hilton

机构信息

Department of Surgery, University of Maryland Medical Center, Baltimore, Md.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Fla.

出版信息

Plast Reconstr Surg Glob Open. 2023 Jan 25;11(1):e4747. doi: 10.1097/GOX.0000000000004747. eCollection 2023 Jan.

DOI:10.1097/GOX.0000000000004747
PMID:36776592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9911196/
Abstract

Tumescent solution utilizing dilute epinephrine and a local anesthetic agent injected into a fat compartment has been shown to effectively minimize blood loss and postoperative pain in liposuction. Ropivacaine has a longer duration of action compared to lidocaine and is a potential analgesic in tumescent solution. We sought to explore the effect of using ropivacaine in a tumescent technique with a focus on its efficacy for pain control postoperatively. The formula for the tumescent technique used combined 1 mL of epinephrine with 30 mL of ropivacaine into 500 mL of injectable saline. Tumescent solution was injected manually into fat donor sites of 10 consecutive patients followed by a 20-minute waiting period before beginning fat aspiration with liposuction cannula. Patients were seen immediately following their surgery and on postoperative day 1 and reported their pain using a numerical scale. Data gathered included the amount of ropivacaine used, average pain rating, and the average amount of fat removed. On average, participants reported little to no pain at the donor sites immediately following surgery and on postoperative day 1. Based on the low need for pain medication, we believe that ropivacaine may be successfully used in tumescent solution to reduce postoperative pain.

摘要

已证明,将含有稀释肾上腺素和局部麻醉剂的肿胀液注射到脂肪层中,可有效减少抽脂术中的失血量和术后疼痛。与利多卡因相比,罗哌卡因的作用持续时间更长,是肿胀液中的一种潜在镇痛药。我们试图探索在肿胀技术中使用罗哌卡因的效果,重点关注其术后疼痛控制效果。所用肿胀技术的配方是将1毫升肾上腺素与30毫升罗哌卡因混合到500毫升可注射盐水中。将肿胀液手动注射到连续10例患者的脂肪供区,然后等待20分钟,再开始用抽脂套管进行脂肪抽吸。患者在术后立即及术后第1天接受检查,并用数字评分法报告疼痛情况。收集的数据包括罗哌卡因的用量、平均疼痛评分和平均抽脂量。平均而言,参与者在术后立即及术后第1天报告供区几乎没有疼痛。基于对止痛药物的低需求,我们认为罗哌卡因可成功用于肿胀液中以减轻术后疼痛。