Liu Yongfei, Yi Yi, Zhong Chengqian, Ma Zecong, Wang Haifeng, Dong Xingmo, Yu Feng, Li Jing, Chen Qinqi, Lin Chaolu, Li Xiaohong
Department of Urology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China.
Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China.
Front Mol Biosci. 2023 Jan 26;10:1121429. doi: 10.3389/fmolb.2023.1121429. eCollection 2023.
With the rapid innovation of nanoscience and technology, nanomaterials have also been deeply applied in the medical and health industry and become one of the innovative methods to treat many diseases. In recent years, bioactive nanomaterials have attracted extensive attention and have made some progress in the treatment of some major chronic diseases, such as nervous system diseases and various malignant tumors. Bioactive nanomaterials depend on their physical and chemical properties (crystal structure, surface charge, surface functional groups, morphology, and size, etc.) and direct produce biological activity and play to the role of the treatment of diseases, compared with the traditional nanometer pharmaceutical preparations, biological active nano materials don't exert effects through drug release, way more directly, also is expected to be more effective for the treatment of diseases. However, further studies are needed in the evaluation of biological effects, fate , structure-activity relationship and clinical transformation of bionanomaterials. Based on the latest research reports, this paper reviews the application of bioactive nanomaterials in the diagnosis and treatment of major chronic diseases and analyzes the technical challenges and key scientific issues faced by bioactive nanomaterials in the diagnosis and treatment of diseases, to provide suggestions for the future development of this field.
随着纳米科学技术的迅速创新，纳米材料也已在医疗卫生行业中得到深入应用，并成为治疗多种疾病的创新方法之一。近年来，生物活性纳米材料引起了广泛关注，并在治疗一些重大慢性病（如神经系统疾病和各种恶性肿瘤）方面取得了一些进展。生物活性纳米材料依靠其物理和化学性质（晶体结构、表面电荷、表面官能团、形态和尺寸等）直接产生生物活性并发挥疾病治疗作用，与传统纳米药物制剂相比，生物活性纳米材料不通过药物释放发挥作用，方式更为直接，也有望在疾病治疗中更有效。然而，在生物纳米材料的生物学效应评估、命运、构效关系及临床转化等方面仍需要进一步研究。基于最新的研究报道，本文综述了生物活性纳米材料在重大慢性病诊断和治疗中的应用，并分析了生物活性纳米材料在疾病诊断和治疗中面临的技术挑战和关键科学问题，为该领域的未来发展提供建议。
