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炎症性肠病患者使用阿片类药物的情况

Opioid Use in Patients With Inflammatory Bowel Disease.

作者信息

Lin Xiwu, Lofland Jennifer, Zhang Ling, Sloan Sheldon, Chamaa Laila, Marano Colleen, Plevy Scott

机构信息

Quantitative Sciences, Janssen Pharmaceutical Research & Development, LLC., Spring House, Pennsylvania, USA.

Janssen Global Services, LLC., Horsham, Pennsylvania, USA.

出版信息

Crohns Colitis 360. 2020 Feb 14;2(1):otaa009. doi: 10.1093/crocol/otaa009. eCollection 2020 Jan.

Abstract

BACKGROUND

Data on opioid use in patients with inflammatory bowel disease and the relationship between disease, opioid use, and healthcare resource utilization are needed.

METHODS

This analysis of real-world data from IBM Watson Health Commercial Claims and Encounters Database included patients with the first claim of inflammatory bowel disease (IBD) between 2007 and 2014.

RESULTS

Opioid use was higher in patients with IBD than in the matched non-IBD cohort. Adjusted for age, gender, and Charlson Comorbidity Index score, inpatient and emergency room visits risk was higher in opioid users than non-users in both IBD cohorts.

CONCLUSIONS

Opioid use could be a potential surrogate for inadequate disease control manifested by increased inpatient and emergency room visit risks. These results suggest a need exists for better disease management and the development of an outcomes measurement tool for IBD pain.

摘要

背景

需要有关炎症性肠病患者使用阿片类药物的数据,以及疾病、阿片类药物使用和医疗资源利用之间的关系。

方法

对来自IBM Watson Health商业索赔和会诊数据库的真实世界数据进行的这项分析纳入了2007年至2014年间首次提出炎症性肠病(IBD)索赔的患者。

结果

IBD患者的阿片类药物使用高于匹配的非IBD队列。在调整年龄、性别和查尔森合并症指数评分后,两个IBD队列中,阿片类药物使用者的住院和急诊就诊风险均高于非使用者。

结论

阿片类药物的使用可能是疾病控制不足的一个潜在替代指标,表现为住院和急诊就诊风险增加。这些结果表明,需要更好地管理疾病,并开发一种用于IBD疼痛的结局测量工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd5a/9802313/03ecff738ab8/otaa009f0001.jpg

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