Procaccini David, Delany Dennis, Self Abigail, Kane Patricia Lawrence, Coulson John D
Department of Pharmacy (DP), The Johns Hopkins Hospital, Baltimore, MD.
Department of Anesthesiology & Critical Care Medicine (DD, AS), The Johns Hopkins Hospital, Baltimore, MD.
J Pediatr Pharmacol Ther. 2023;28(1):102-107. doi: 10.5863/1551-6776-28.1.102. Epub 2023 Feb 3.
We report a case of a 7-year old male with idiopathic pulmonary arterial hypertension, successfully transitioned from an intravenous infusion to inhaled treprostinil during inpatient admission, after his intentional removal of multiple central venous catheters. He had no clinical, echocardiographic, or serum biomarker evidence of loss of control of pulmonary arterial hypertension during the 4-day transition. The patient was discharged home without complications, and 3 weeks after discharge the patient's pulmonary hypertension remained well controlled per clinical and echocardiographic evidence, including a significantly improved 6-minute walk distance test.
我们报告一例7岁男性特发性肺动脉高压患者,在其故意拔除多根中心静脉导管后,于住院期间成功从静脉输注过渡到吸入曲前列尼尔治疗。在4天的过渡期间,他没有出现肺动脉高压控制不佳的临床、超声心动图或血清生物标志物证据。患者出院时无并发症,出院3周后,根据临床和超声心动图证据,患者的肺动脉高压仍得到良好控制,包括6分钟步行距离测试显著改善。