Hyun Ye Ji, Park Soo-Yeon, Kim Ji Yeon
Department of Food Science and Technology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Republic of Korea.
Department of Nano Bio Engineering, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Republic of Korea.
Food Sci Biotechnol. 2022 Nov 9;32(3):371-379. doi: 10.1007/s10068-022-01198-6. eCollection 2023 Mar.
This study aimed to evaluate the effect of fermented rice germ extracts on the inhibition of glucose uptake in the gastrointestinal (GI) tract. Samples were prepared by extracting rice germ fermented with with 30% ethanol (RG_30E) or 50% ethanol (RG_50E). Ferulic acid was determined as the active component in the samples. RG_30E significantly inhibited glucose uptake and mRNA expression of GLUT2 and SGLT1 to a larger extent than RG_50E in Caco-2 cells. A single oral administration was performed on C57BL/6 mice to confirm which substrate (glucose, sucrose, or maltose) the sample inhibited absorption of, improving postprandial blood glucose elevation. As a result, RG_30E resulted in significantly lower blood glucose levels and AUC after glucose and sucrose administration. Therefore, fermented rice germ extracted with 30% ethanol regulates glucose uptake through glucose transporters and can be expected to alleviate postprandial hyperglycemia in the GI tract.
The online version contains supplementary material available at 10.1007/s10068-022-01198-6.
本研究旨在评估发酵米胚芽提取物对胃肠道（GI）葡萄糖摄取的抑制作用。样品通过提取用30%乙醇（RG_30E）或50%乙醇（RG_50E）发酵的米胚芽制备。阿魏酸被确定为样品中的活性成分。在Caco - 2细胞中，RG_30E比RG_50E更显著地抑制葡萄糖摄取以及GLUT2和SGLT1的mRNA表达。对C57BL/6小鼠进行单次口服给药，以确认样品抑制哪种底物（葡萄糖、蔗糖或麦芽糖）的吸收，改善餐后血糖升高。结果，RG_30E在给予葡萄糖和蔗糖后导致显著更低的血糖水平和曲线下面积（AUC）。因此，用30%乙醇提取的发酵米胚芽通过葡萄糖转运蛋白调节葡萄糖摄取，并有望减轻胃肠道的餐后高血糖。
在线版本包含可在10.1007/s10068 - 022 - 01198 - 6获取的补充材料。
