Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades-2° Piso CORSE Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, CP 06720 Ciudad de México, Mexico.
Instituto Politécnico Nacional, Escuela Superior de Medicina, IPN, Salvador Díaz Mirón esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, CP 11340 Ciudad de México, Mexico.
Molecules. 2021 Feb 11;26(4):947. doi: 10.3390/molecules26040947.
Ortega was evaluated to determinate its antihyperglycemic and lipid profile properties. Petroleum ether extract of fresh aerial parts of (PEfAPSa) and a secondary fraction (F6Sa) were evaluated to determine their antihyperglycemic activity in streptozo-cin-induced diabetic (STID) mice, in oral tolerance tests of sucrose, starch, and glucose (OSTT, OStTT, and OGTT, respectively), in terms of glycated hemoglobin (HbA1c), triglycerides (TG), and high-density lipoprotein (HDL). In acute assays at doses of 50 mg/kg body weight (b.w.), PEfAPSa and F6Sa showed a reduction in hyperglycemia in STID mice, at the first and fifth hour after of treatment, respectively, and were comparable with acarbose. In the sub-chronic test, PEfAPSa and F6Sa showed a reduction of glycemia since the first week, and the effect was greater than that of the acarbose control group. In relation to HbA1c, the treatments prevented the increase in HbA1c. In the case of TG and HDL, PEfAPSa and F6Sa showed a reduction in TG and an HDL increase from the second week. OSTT and OStTT showed that PEfAPSa and F6Sa significantly lowered the postprandial peak at 1 h after loading but only in sucrose or starch such as acarbose. The results suggest that activity may be mediated by the inhibition of disaccharide hydrolysis, which may be associated with an α-glucosidase inhibitory effect.
奥尔特加被评估以确定其降血糖和血脂谱特性。新鲜地上部分的石油醚提取物（PEfAPSa）和一个次级馏分（F6Sa）被评估以确定它们在链脲佐菌素诱导的糖尿病（STID）小鼠中的降血糖活性，在蔗糖、淀粉和葡萄糖的口服耐受试验（OSTT、OStTT 和 OGTT）中，分别从糖化血红蛋白（HbA1c）、甘油三酯（TG）和高密度脂蛋白（HDL）的角度来看。在 50mg/kg 体重（b.w.）的剂量下进行急性测定时，PEfAPSa 和 F6Sa 在治疗后第一和第五小时分别显示出 STID 小鼠的高血糖降低，与阿卡波糖相当。在亚慢性试验中，PEfAPSa 和 F6Sa 自第一周开始显示出降低血糖的作用，其作用大于阿卡波糖对照组。关于 HbA1c，治疗预防了 HbA1c 的增加。就 TG 和 HDL 而言，PEfAPSa 和 F6Sa 显示 TG 降低，HDL 从第二周开始增加。OSTT 和 OStTT 表明，PEfAPSa 和 F6Sa 显著降低了负荷后 1 小时的餐后峰值，但仅在蔗糖或淀粉中，如阿卡波糖。结果表明，的活性可能是通过抑制二糖水解介导的，这可能与α-葡萄糖苷酶抑制作用有关。
