Tran Bach Xuan, Nguyen Tham Thi, Boyer Laurent, Fond Guillaume, Auquier Pascal, Nguyen Hao Si Anh, Tran Ha Thi Nhi, Nguyen Hung Manh, Choi Jongkwan, Le Huong Thi, Latkin Carl A, Nathan Kalpana Isabel, Husain Syeda F, McIntyre Roger S, Ho Cyrus S H, Zhang Melvyn W B, Ho Roger C M
Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.
EA 3279, CEReSS, Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France.
Front Psychiatry. 2023 Jan 26;14:1061284. doi: 10.3389/fpsyt.2023.1061284. eCollection 2023.
This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks.
One hundred fifty-seven participants were divided into schizophrenia ( = 110) and healthy controls group ( = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area.
People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731-0.872). The Youden's index reached a peak (0.57) at the optimal cut-point value (HbO cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%.
Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries.
本研究旨在评估便携式功能近红外光谱（fNIRS）设备作为越南辅助诊断工具，用于评估精神分裂症患者和健康对照者执行认知任务时的血流动力学情况。
157名参与者按年龄和性别匹配分为精神分裂症组（n = 110）和健康对照组（n = 47）。在斯特鲁普颜色-文字测试（SCWT）和语言流畅性测试（VFT）期间，使用48通道便携式设备监测额叶皮质的血流动力学反应。采用一般线性模型比较两组之间氧合血红蛋白（HbO）水平的差异。为每个神经解剖区域绘制受试者工作特征（ROC）曲线。
与任务前相比，精神分裂症患者在SCWT和VFT期间额叶未显示出明显激活。在VFT期间，双侧背外侧前额叶皮质、双侧眶额叶皮质、双侧额极前额叶皮质和双侧腹外侧前额叶皮质的ROC曲线下面积大于0.7（p < 0.001）。右侧眶额叶皮质在VFT期间的ROC曲线下面积（AUC）最大（AUC = 0.802，95%CI = 0.731 - 0.872）。在最佳切点值（精神分裂症的HbO截止值<0.209 μmol/ml）时，约登指数达到峰值（0.57），此时灵敏度为85%；特异性为72%；阳性预测值（PPV）为0.88；阴性预测值（NPV）为0.68，正确分类率为76%。
通过便携式fNIRS评估VFT期间的血流动力学情况，为发展中国家精神分裂症的辅助诊断工具提供了潜力。
