Rose Michael J, LaValley Michael P, Jafarzadeh S Reza, Costello Kerry E, Shah Nirali, Lee Soyoung, Borrelli Belinda, Messier Stephen P, Neogi Tuhina, Kumar Deepak
Department of Physical Therapy & Athletic Training, Boston University, Boston, MA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA.
J Meas Phys Behav. 2022 Dec;5(4):294-298. doi: 10.1123/jmpb.2022-0019. Epub 2022 Sep 28.
To examine changes in physical activity, sleep, pain and mood in people with knee osteoarthritis (OA) during the ongoing COVID-19 pandemic by leveraging an ongoing randomized clinical trial (RCT).
Participants enrolled in a 12-month parallel two-arm RCT (NCT03064139) interrupted by the COVID-19 pandemic wore an activity monitor (Fitbit Charge 3) and filled out custom weekly surveys rating knee pain, mood, and sleep as part of the study. Data from 30 weeks of the parent study were used for this analysis. Daily step count and sleep duration were extracted from activity monitor data, and participants self-reported knee pain, positive mood, and negative mood via surveys. Metrics were averaged within each participant and then across all participants for pre-pandemic, stay-at-home, and reopening periods, reflecting the phased re-opening in the state of Massachusetts.
Data from 28 participants showed small changes with inconclusive clinical significance during the stay-at-home and reopening periods compared to pre-pandemic for all outcomes. Summary statistics suggested substantial variability across participants with some participants showing persistent declines in physical activity during the observation period.
Effects of the COVID-19 pandemic on physical activity, sleep, pain, and mood were variable across individuals with OA. Specific reasons for this variability could not be determined. Identifying factors that could affect individuals with knee OA who may exhibit reduced physical activity and/or worse symptoms during major lifestyle changes (such as the ongoing pandemic) is important for providing targeted healthcare services and management advice towards those that could benefit from it the most.
通过一项正在进行的随机临床试验（RCT），研究在持续的新冠疫情期间膝骨关节炎（OA）患者的身体活动、睡眠、疼痛和情绪变化。
参加一项为期12个月的平行双臂RCT（NCT03064139）的参与者，该试验因新冠疫情而中断，他们佩戴活动监测器（Fitbit Charge 3）并填写定制的每周调查问卷，对膝盖疼痛、情绪和睡眠进行评分，作为研究的一部分。本分析使用了母研究30周的数据。从活动监测器数据中提取每日步数和睡眠时间，参与者通过调查问卷自我报告膝盖疼痛、积极情绪和消极情绪。在每个参与者内部对指标进行平均，然后在所有参与者中对大流行前、居家和重新开放期间的指标进行平均，反映马萨诸塞州的分阶段重新开放情况。
28名参与者的数据显示，与大流行前相比，在居家和重新开放期间所有结果的变化都很小，临床意义不明确。汇总统计数据表明，参与者之间存在很大差异，一些参与者在观察期内身体活动持续下降。
新冠疫情对OA患者的身体活动、睡眠、疼痛和情绪的影响因人而异。无法确定这种差异的具体原因。识别在重大生活方式改变（如持续的疫情）期间可能表现出身体活动减少和/或症状恶化的膝OA患者的影响因素，对于为那些最能从中受益的人提供有针对性的医疗服务和管理建议非常重要。
