Cisternas Alvaro F, Ramachandran Roshni, Yaksh Tony L, Nahama Alexis
Sorrento Therapeutics Inc, San Diego, CA, USA.
Department of Anesthesiology, UCSD, San Diego, CA, USA.
Pain Rep. 2020 Oct 12;5(6):e855. doi: 10.1097/PR9.0000000000000855. eCollection 2020 Nov-Dec.
In recent months, with the emergence of the COVID-19 pandemic, the American College of Surgeons and the U.S. Centers for Disease Control and Prevention officially recommended the delay of nonemergency procedures until the public health crisis is resolved. Deferring elective joint replacement surgeries for an unknown period is likely to decrease the incidence of infection with SARS-CoV-2 but is likely to have detrimental effects in individuals suffering from chronic knee pain. These detrimental effects extend beyond the discomfort of osteoarthritis (OA) and the inconvenience of rescheduling surgery. Disabling pain is a driving factor for individuals to seek medical intervention, including pharmacological palliative treatment and surgical procedures. The need for surgical intervention due to chronic pain as for knee and hip replacement is now put on hold indefinitely because access to surgical care has been limited. Although a moderate delay in surgical intervention may not produce a significant progression of OA within the knee, it could lead to muscle wasting due to immobility and exacerbate comorbidities, making rehabilitation more challenging. Importantly, it will have an impact on comorbidities driven by OA severity, notably decreased quality of life and depression. These patients with unremitting pain become increasingly susceptible to substance use disorders including opioids, alcohol, as well as prescription and illegal drugs. Appreciation of this downstream crisis created by delayed surgical correction requires aggressive consideration of nonsurgical, nonopiate supported interventions to reduce the morbidity associated with these delays brought upon by the currently restricted access to joint repair.
近几个月来,随着新冠疫情的出现,美国外科医师学会和美国疾病控制与预防中心正式建议推迟非紧急手术,直至公共卫生危机得到解决。在一段未知的时期内推迟择期关节置换手术可能会降低感染新冠病毒的发生率,但可能会对患有慢性膝关节疼痛的个体产生不利影响。这些不利影响不仅限于骨关节炎(OA)带来的不适以及重新安排手术带来的不便。致残性疼痛是促使个体寻求医疗干预的一个驱动因素,包括药物姑息治疗和外科手术。由于慢性疼痛而需要进行膝关节和髋关节置换等外科手术干预的需求,现在因获得手术治疗的机会有限而被无限期搁置。虽然手术干预的适度延迟可能不会导致膝关节内OA的显著进展,但可能会因活动受限导致肌肉萎缩,并加重合并症,使康复更具挑战性。重要的是,这将对由OA严重程度驱动的合并症产生影响,尤其是生活质量下降和抑郁。这些持续疼痛的患者越来越容易出现物质使用障碍,包括阿片类药物、酒精以及处方药和非法药物。认识到延迟手术矫正所造成的这一后续危机,需要积极考虑非手术、非阿片类支持的干预措施,以降低因目前关节修复治疗机会受限所带来的这些延迟相关的发病率。