Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, 210006, Nanjing, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
J Mater Chem B. 2023 Jun 21;11(24):5523-5536. doi: 10.1039/d2tb02056d.
Biomimetic materials with complicated structures inspired by natural plants play a critical role in tissue engineering. The succulent plants, with complicated morphologies, show tenacious vitality in extreme conditions due to the physiological functions endowed by their unique anatomical structures. Herein, inspired by the macroscopic structure of succulent plants, succulent plant-like bioceramic scaffolds were fabricated digital laser processing 3D printing of MgSiO. Compared with conventional scaffolds with interlaced columns, the structures could prevent cells from leaking from the scaffolds and enhance cell adhesion. The scaffold morphology could be well regulated by changing leaf sizes, shapes, and interlacing methods. The succulent plant-like scaffolds show excellent properties for cell loading as well as cell distribution, promoting cellular interplay, and further enhancing the osteogenic differentiation of bone marrow stem cells. The study further illustrated that the succulent plant-like scaffolds could accelerate bone regeneration by inducing the formation of new bone tissues. The study suggests that the obtained succulent plant-like scaffold featuring the plant macroscopic structure is a promising biomaterial for regulating cell distribution, enhancing cellular interactions, and further improving bone regeneration.
受自然植物启发的具有复杂结构的仿生材料在组织工程中起着关键作用。肉质植物由于其独特的解剖结构赋予的生理功能，具有顽强的生命力，即使在极端条件下也能生存。在此，受肉质植物宏观结构的启发，通过数字激光加工 3D 打印 MgSiO，制备了肉质植物样生物陶瓷支架。与具有交错柱的传统支架相比，这种结构可以防止细胞从支架中漏出，并增强细胞黏附。通过改变叶片的大小、形状和交错方式，可以很好地调节支架的形态。肉质植物样支架具有良好的细胞负载和细胞分布性能，促进细胞相互作用，进一步增强骨髓干细胞的成骨分化。研究进一步表明，肉质植物样支架可以通过诱导新骨组织的形成来加速骨再生。该研究表明，获得的具有植物宏观结构的肉质植物样支架是一种很有前途的调节细胞分布、增强细胞相互作用、进一步改善骨再生的生物材料。
