Ningbo Innovation Center, College of Biosystems Engineering and Food Science, Zhejiang University, Ningbo, Zhejiang, China.
Department of Food Science, Cornell University, Ithaca, New York, USA.
Crit Rev Food Sci Nutr. 2024;64(20):6902-6923. doi: 10.1080/10408398.2023.2176816. Epub 2023 Feb 13.
The antioxidant and anti-inflammatory properties of astaxanthin (AST) enable it to protect against oxidative stress-related and inflammatory diseases with a range of biological effects. These activities provide the potential to develop healthier food products. Therefore, it would be beneficial to design delivery systems for AST to overcome its low stability, control its release, and/or improve its bioavailability. This review discusses the basis for AST's various biological activities and the factors limiting these activities, including stability, solubility, and bioavailability. It also discusses the different systems available for the targeted delivery of AST and their applications in enhancing the biological activity of AST. These include systems that are candidates for preventive and therapeutic effects, which include nerves, liver, and skin, particularly for possible cancer reduction. Targeted delivery of AST to specific regions of the gastrointestinal tract, or more selectively to target tissues and cells, can be achieved using targeted delivery systems to increase the biological activities of AST.
虾青素（AST）具有抗氧化和抗炎特性，能够通过多种生物学效应来预防与氧化应激相关的和炎症性疾病。这些活性为开发更健康的食品产品提供了潜力。因此，设计用于 AST 的输送系统以克服其低稳定性、控制其释放和/或提高其生物利用度将是有益的。本文综述了 AST 各种生物学活性的基础以及限制这些活性的因素，包括稳定性、溶解度和生物利用度。它还讨论了用于 AST 靶向递送的不同系统及其在增强 AST 生物学活性中的应用。这些系统包括候选的预防和治疗效果系统，包括神经、肝脏和皮肤，特别是可能减少癌症。通过靶向输送系统将 AST 靶向递送至胃肠道的特定区域，或更选择性地递送至靶组织和细胞，可提高 AST 的生物学活性。
