• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新的虾青素定制纳米液滴载体可以改善其药代动力学特性以及抗氧化和抗炎功效。

A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies.

机构信息

Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.

Lyotropic Delivery Systems Ltd., Hi-Tech Park, Row 5(1), Edmond J. Safra Campus, Jerusalem 9139002, Israel.

出版信息

Int J Mol Sci. 2024 Jul 18;25(14):7861. doi: 10.3390/ijms25147861.

DOI:10.3390/ijms25147861
PMID:39063101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11276774/
Abstract

Astaxanthin (ATX) is a carotenoid nutraceutical with poor bioavailability due to its high lipophilicity. We tested a new tailored nanodroplet capable of solubilizing ATX in an oil-in-water micro-environment (LDS-ATX) for its capacity to improve the ATX pharmacokinetic profile and therapeutic efficacy. We used liquid chromatography tandem mass spectrometry (LC-MS/MS) to profile the pharmacokinetics of ATX and LDS-ATX, superoxide mutase (SOD) activity to determine their antioxidant capacity, protein carbonylation and lipid peroxidation to compare their basal and lipopolysaccharide (LPS)-induced oxidative damage, and ELISA-based detection of IL-2 and IFN-γ to determine their anti-inflammatory capacity. ATX and LDS-ATX corrected only LPS-induced SOD inhibition and oxidative damage. SOD activity was restored only by LDS-ATX in the liver and brain and by both ATX and LDS-ATX in muscle. While in the liver and muscle, LDS-ATX attenuated oxidative damage to proteins and lipids better than ATX; only oxidative damage to lipids was preferably corrected by LDS-ATX in the brain. IL-2 and IFN-γ pro-inflammatory response was corrected by LDS-ATX and not ATX in the liver and brain, but in muscle, the IL-2 response was not corrected and the IFN-γ response was mitigated by both. These results strongly suggest an organ-dependent improvement of ATX bioavailability and efficacy by the LDS-ATX nanoformulation.

摘要

虾青素（ATX）是一种类胡萝卜素营养保健品，由于其高亲脂性，生物利用度较差。我们测试了一种新的定制纳米液滴，能够在油包水微环境中溶解 ATX（LDS-ATX），以提高 ATX 的药代动力学特征和治疗效果。我们使用液相色谱串联质谱（LC-MS/MS）来描述 ATX 和 LDS-ATX 的药代动力学，超氧化物歧化酶（SOD）活性来确定其抗氧化能力，蛋白质羰基化和脂质过氧化来比较其基础和脂多糖（LPS）诱导的氧化损伤，以及基于 ELISA 的检测白细胞介素 2（IL-2）和干扰素-γ（IFN-γ）来确定其抗炎能力。ATX 和 LDS-ATX 仅纠正 LPS 诱导的 SOD 抑制和氧化损伤。只有 LDS-ATX 能在肝脏和大脑中恢复 SOD 活性，而 ATX 和 LDS-ATX 均能在肌肉中恢复 SOD 活性。虽然在肝脏和肌肉中，LDS-ATX 对蛋白质和脂质的氧化损伤的纠正作用优于 ATX，但只有 LDS-ATX 能更好地纠正大脑中的脂质氧化损伤。LDS-ATX 而非 ATX 能纠正肝脏和大脑中 IL-2 和 IFN-γ 的促炎反应，但在肌肉中，IL-2 反应未被纠正，IFN-γ 反应则被两者减轻。这些结果强烈表明，LDS-ATX 纳米制剂能改善 ATX 的生物利用度和疗效，且具有器官依赖性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/7805d39f63a1/ijms-25-07861-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/e1331f73fb0e/ijms-25-07861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/ca739a1126f8/ijms-25-07861-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/071963bfbc34/ijms-25-07861-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/c325ec5b0f26/ijms-25-07861-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/48403c780b5e/ijms-25-07861-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/82d6c6aa0d83/ijms-25-07861-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/8a7a2f9c3c3c/ijms-25-07861-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/757337a4a6d1/ijms-25-07861-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/2643745a712e/ijms-25-07861-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/73685d3bb5bb/ijms-25-07861-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/bfaa8f691ec7/ijms-25-07861-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/7805d39f63a1/ijms-25-07861-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/e1331f73fb0e/ijms-25-07861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/ca739a1126f8/ijms-25-07861-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/071963bfbc34/ijms-25-07861-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/c325ec5b0f26/ijms-25-07861-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/48403c780b5e/ijms-25-07861-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/82d6c6aa0d83/ijms-25-07861-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/8a7a2f9c3c3c/ijms-25-07861-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/757337a4a6d1/ijms-25-07861-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/2643745a712e/ijms-25-07861-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/73685d3bb5bb/ijms-25-07861-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/bfaa8f691ec7/ijms-25-07861-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a8/11276774/7805d39f63a1/ijms-25-07861-g012.jpg

相似文献

1
A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies.一种新的虾青素定制纳米液滴载体可以改善其药代动力学特性以及抗氧化和抗炎功效。
Int J Mol Sci. 2024 Jul 18;25(14):7861. doi: 10.3390/ijms25147861.
2
Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats.虾青素可减轻大鼠完全弗氏佐剂诱导的关节炎中的氧化应激和炎症反应。
Pharmacol Rep. 2020 Feb;72(1):104-114. doi: 10.1007/s43440-019-00022-z. Epub 2019 Dec 19.
3
Protective effect of astaxanthin on ANCA-associated vasculitis.虾青素对 ANCA 相关性血管炎的保护作用。
Int Immunopharmacol. 2024 May 10;132:111928. doi: 10.1016/j.intimp.2024.111928. Epub 2024 Mar 26.
4
Chitosan-graft-poly(lactide) nanocarriers: An efficient antioxidant delivery system for combating oxidative stress.壳聚糖接枝聚乳酸纳米载体：一种用于对抗氧化应激的高效抗氧化剂递送系统。
Int J Biol Macromol. 2024 Nov;279(Pt 1):135280. doi: 10.1016/j.ijbiomac.2024.135280. Epub 2024 Sep 30.
5
Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects.载虾青素聚合物-脂质杂化纳米粒（ATX-LPN）：潜在的耳保护作用评估。
J Nanobiotechnology. 2020 Mar 19;18(1):53. doi: 10.1186/s12951-020-00600-x.
6
Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice.虾青素对环磷酰胺诱导的氧化应激和DNA损伤的干预作用：一项小鼠研究
Chem Biol Interact. 2009 Aug 14;180(3):398-406. doi: 10.1016/j.cbi.2009.03.017. Epub 2009 Apr 2.
7
[Effects of Astaxanthin on the damage of osteoblast induced by H2O2].虾青素对过氧化氢诱导的成骨细胞损伤的影响
Zhongguo Gu Shang. 2008 Mar;21(3):187-9.
8
Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control.虾青素为脂多糖诱导的树突状细胞提供抗氧化保护，以控制炎症。
Mar Drugs. 2021 Sep 23;19(10):534. doi: 10.3390/md19100534.
9
Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage.虾青素对实验性蛛网膜下腔出血后氧化应激的改善和早期脑损伤的保护作用。
J Neurosurg. 2014 Jul;121(1):42-54. doi: 10.3171/2014.2.JNS13730. Epub 2014 Apr 11.
10
Water-dispersible astaxanthin-rich nanopowder: preparation, oral safety and antioxidant activity in vivo.水分散性富虾青素纳米粉末：制备、口服安全性和体内抗氧化活性。
Food Funct. 2019 Mar 20;10(3):1386-1397. doi: 10.1039/c8fo01593g.

本文引用的文献

1
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs.树突状细胞在肝内形成网络，在淋巴器官外辅助 CD4 T 细胞。
Nat Commun. 2024 Feb 10;15(1):1261. doi: 10.1038/s41467-024-45612-5.
2
Anticancer Activity of Astaxanthin-Incorporated Chitosan Nanoparticles.虾青素壳聚糖纳米粒的抗癌活性
Molecules. 2024 Jan 21;29(2):529. doi: 10.3390/molecules29020529.
3
Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis.饮食虾青素：大脑衰老和成人神经发生的有前途的抗氧化剂和抗炎剂。
Mar Drugs. 2023 Dec 16;21(12):643. doi: 10.3390/md21120643.
4
Micro-algal astaxanthin ameliorates polystyrene microplastics-triggered necroptosis and inflammation by mediating mitochondrial Ca homeostasis in carp's head kidney lymphocytes (Cyprinus carpio L.).微藻虾青素通过调节鲤鱼头肾淋巴细胞中线粒体钙稳态缓解聚苯乙烯微塑料诱导的细胞坏死和炎症。
Fish Shellfish Immunol. 2023 Dec;143:109205. doi: 10.1016/j.fsi.2023.109205. Epub 2023 Oct 31.
5
Preparation of astaxanthin-loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability.同轴电喷雾技术制备载虾青素复合胶束以提高口服生物利用度和改善抗氧化能力。
J Sci Food Agric. 2024 Feb;104(3):1408-1419. doi: 10.1002/jsfa.13019. Epub 2023 Nov 15.
6
β-Glucan Regulates Lipopolysaccharide Induced Genotoxic Damage to The Liver through The Induction of BRCA1 Protein Expression.β-葡聚糖通过诱导BRCA1蛋白表达调节脂多糖诱导的肝脏基因毒性损伤。
Cell J. 2023 Sep 9;25(9):645-654. doi: 10.22074/cellj.2023.1989382.1226.
7
More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines.不止是色素：虾青素和细菌红素基纳米药物的潜力
Pharmaceutics. 2023 Jun 26;15(7):1828. doi: 10.3390/pharmaceutics15071828.
8
Unveiling the Mechanism of Alleviating Ischemia Reperfusion Injury a Layered Double Hydroxide-Based Nanozyme.揭示基于层状双氢氧化物的纳米酶减轻缺血再灌注损伤的机制
ACS Appl Mater Interfaces. 2023 Mar 22;15(11):13869-13878. doi: 10.1021/acsami.2c19570. Epub 2023 Mar 13.
9
Improving the biological activities of astaxanthin using targeted delivery systems.利用靶向递送系统提高虾青素的生物活性。
Crit Rev Food Sci Nutr. 2024;64(20):6902-6923. doi: 10.1080/10408398.2023.2176816. Epub 2023 Feb 13.
10
Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines.血管紧张素Ⅱ型受体药理学激动剂通过减少神经炎症和小胶质细胞吞噬树突棘来缓解神经认知缺陷。
J Neuroimmune Pharmacol. 2023 Jun;18(1-2):41-57. doi: 10.1007/s11481-022-10054-7. Epub 2022 Dec 5.