Musci G, Silvestrini B
Department of Biochemical Sciences, University of Rome La Sapienza, Italy.
Drugs Exp Clin Res. 1987;13(5):289-92.
By using EPR spectroscopy of spin-labelled bovine serum albumin (BSA), bendazac was shown to prevent the BSA denaturation induced by urea, heat and free radicals produced in the xanthine/xanthine oxidase system. Bendazac did not inhibit the reduction of ferricytochrome c due to the superoxide flux in the above system nor did it possess a significant antioxidant activity on Fe(II) or Fe(III)-induced peroxidation of lecithin liposomes. It is concluded that the scavenger-like activity of bendazac is due to its interaction with protein molecules, rather than free radicals.
通过使用自旋标记牛血清白蛋白（BSA）的电子顺磁共振光谱法，已表明苄达酸可防止由尿素、热以及黄嘌呤/黄嘌呤氧化酶系统产生的自由基所诱导的BSA变性。苄达酸并不抑制上述系统中由于超氧阴离子通量导致的高铁细胞色素c的还原，并且它对Fe（II）或Fe（III）诱导的卵磷脂脂质体过氧化也不具有显著的抗氧化活性。得出的结论是，苄达酸的类似清除剂的活性是由于它与蛋白质分子的相互作用，而非与自由基的相互作用。
