苄达酸在兔眼的药代动力学研究。

Investigations on the ocular pharmacokinetics of bendazac in rabbits.

作者信息

Valeri P, Palmery M, Tita B, Silvestrini B

出版信息

Exp Mol Pathol. 1985 Dec;43(3):283-7. doi: 10.1016/0014-4800(85)90065-6.

Abstract

The ocular pharmacokinetics of bendazac were studied in rabbits, following intravenous administration of bendazac lysine. The compound and its 5-hydroxyderivative were determined in different eye compartments and plasma by radioassay, using [14C]bendazac, and HPLC. The highest concentrations were found in the iris and in descending order in the ciliary body, retina, cornea, tears, aqueous humor, vitreous, and lens. The time course of concentrations in the plasma, aqueous and vitreous humor, ciliary body, and retina showed kinetics described by the exponential equation y = aebx with a half-life of 2.47, 4.56, 3.59, and 3.22 hr, respectively; in the lens the half-life was 17.77 hr.

摘要

在静脉注射苄达赖氨酸后，对家兔体内苄达酸的眼药代动力学进行了研究。使用[14C]苄达酸和高效液相色谱法，通过放射测定法在不同眼房和血浆中测定该化合物及其5-羟基衍生物。在虹膜中发现的浓度最高，在睫状体、视网膜、角膜、泪液、房水、玻璃体和晶状体中的浓度依次降低。血浆、房水和玻璃体液、睫状体和视网膜中浓度的时间进程显示其动力学符合指数方程y = aebx，半衰期分别为2.47、4.56、3.59和3.22小时；晶状体中的半衰期为17.77小时。