Foltin R W, Brady J V, Fischman M W, Emurian C S, Dominitz J
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Drug Alcohol Depend. 1987 Sep;20(1):87-93. doi: 10.1016/0376-8716(87)90079-2.
Twelve adult male research volunteers, in four groups of three subjects each, resided continuously in a residential laboratory for up to 18 days. Subject's behaviors, including social interaction, were continuously recorded. During the first part of the day (1000-1600), subjects remained in their private rooms doing work activities, and during the remainder of the day (1600-2345), they had the option to socialize with the other subjects. Four cigarettes containing active marijuana (1.84%, delta 9-tetrahydrocannabinol (delta 9 (THC)), w/w) or placebo were smoked daily: one each prior to the work and social access period, and two during the social access period. When the results were averaged across all groups and individuals, active marijuana significantly increased total daily social interaction time. However, drug effects were a function of the baseline amount of social interaction. The results of these experiments also showed that the pattern of increases in social interaction following smoked active marijuana varied within different groups of individuals.
12名成年男性研究志愿者被分成四组,每组三人,在一个居住式实验室中连续居住长达18天。对受试者的行为,包括社交互动,进行持续记录。在一天的前半段时间(10:00 - 16:00),受试者待在自己的私人房间里进行工作活动,而在一天的其余时间(16:00 - 23:45),他们可以选择与其他受试者进行社交。每天吸食四支含有活性大麻(1.84%,Δ9 - 四氢大麻酚(Δ9(THC)),重量/重量)或安慰剂的香烟:在工作和社交活动时间段之前各吸一支,在社交活动时间段吸两支。当对所有组和个体的结果进行平均时,活性大麻显著增加了每日总的社交互动时间。然而,药物效果是社交互动基线量的一个函数。这些实验的结果还表明,吸食活性大麻后社交互动增加的模式在不同个体组中有所不同。