Postgraduate program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
Undergraduate program in the Faculty of Dentistry, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil.
Photodiagnosis Photodyn Ther. 2023 Jun;42:103331. doi: 10.1016/j.pdpdt.2023.103331. Epub 2023 Feb 11.
Pericoronitis is a common disease that impacts the quality of life of individuals during the eruption of the third molars. Among the main clinical signs and symptoms reported were the presence of gingival operculum, pain, difficulty swallowing, and trismus with functional impairment. The present study shows a case report of pericoronitis treated with antimicrobial photodynamic therapy (aPDT), using a new oral formulation (INPI BR 1020170253902) of methylene blue. A female patient, 27 years old, presenting initial pericoronitis, had her pain, mouth opening, and swelling evaluated. She was submitted to a protocol of irrigation with sterile saline and photodynamic therapy using the new MB at 0.005% concentration and irradiation with low-intensity laser λ = 660 nm, 9 J per point, and radiant exposure of 318 J/cm. The variables were evaluated on 4th day after aPDT. There was a 100% improvement in pain and an increase of 1,3 cm in mouth opening. There was no difference in the edema before and after aPDT using the new MB formula. Although the results are based on a single case report, suggest the hypothesis that aPDT using the new MB formula is an efficient therapy in the treatment of pain and trismus caused by the early stage of pericoronitis. Well-conducted randomized clinical trials are needed to compare this new formulation with conventional aPDT for further generalization of results.
智齿冠周炎是一种常见疾病，会影响第三磨牙萌出期间个体的生活质量。主要报道的临床体征和症状包括牙龈盖、疼痛、吞咽困难和张口受限伴功能障碍。本研究报告了一例使用新型口腔配方（INPI BR 1020170253902）亚甲蓝治疗的智齿冠周炎病例。一位 27 岁的女性患者，最初患有智齿冠周炎，其疼痛、张口度和肿胀情况得到了评估。她接受了无菌生理盐水冲洗和光动力疗法的方案，使用新的 MB 浓度为 0.005%，低强度激光 λ=660nm，每个点 9J，辐射暴露量为 318J/cm。在 aPDT 后第 4 天评估了变量。疼痛的改善率达到 100%，张口度增加了 1.3cm。使用新 MB 配方前后的肿胀没有差异。尽管结果基于单个病例报告，但表明使用新型 MB 配方的 aPDT 是治疗早期智齿冠周炎引起的疼痛和张口受限的有效治疗方法。需要进行良好设计的随机临床试验来比较这种新配方与传统 aPDT，以进一步推广结果。
