癌症化疗耐药性发展的数学模型。

A mathematical model of the development of drug resistance to cancer chemotherapy.

作者信息

Birkhead B G, Rankin E M, Gallivan S, Dones L, Rubens R D

机构信息

Department of Statistical Science, University College London.

出版信息

Eur J Cancer Clin Oncol. 1987 Sep;23(9):1421-7. doi: 10.1016/0277-5379(87)90133-7.

DOI:10.1016/0277-5379(87)90133-7

PMID:3678329

Abstract

A mathematical model incorporating descriptions of tumour growth kinetics and the effects of cytotoxic chemotherapy on established tumours, is presented. It is shown how models of this kind may be used to investigate the potential of hypothetical chemotherapy strategies, and to identify general principles for successful treatment. The model is intended to be an aid to clinicians designing new chemotherapy programmes for diseases in which progress has been disappointing.

摘要

本文提出了一个数学模型，该模型纳入了肿瘤生长动力学的描述以及细胞毒性化疗对已形成肿瘤的影响。展示了如何使用这类模型来研究假设的化疗策略的潜力，并确定成功治疗的一般原则。该模型旨在帮助临床医生为进展令人失望的疾病设计新的化疗方案。