González J, Muñoz M E, Esteller A
Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
Exp Pathol. 1987;32(2):89-93. doi: 10.1016/s0232-1513(87)80062-2.
The interrelationship between the biliary secretion of phospholipids, bilirubin and bile acids was studied in New Zealand rabbits after acinar zone 3 hepatocyte damage induced by bromobenzene (4 mmol/kg body wt; i.p.). Treatment with the toxin did not significantly modify biliary phospholipid secretion, suggesting that the transport of phospholipids is mainly a zone 1 function. Bilirubin infusion at 1 mumol/min kg body wt induced a significant inhibition in biliary phospholipid secretion both in control and treated animals. This effect was overcome by the additional infusion of sodium glycodeoxycholate at 1.6 mumol/min kg body wt, although higher increases in phospholipid output were found in the control than in the treated rabbits. This would be related to the lowered recruitment of zone 3 cells for secretion in bromobenzene-damaged livers.
在给新西兰兔腹腔注射溴苯（4 mmol/kg体重）诱导3区腺泡肝细胞损伤后，研究了磷脂、胆红素和胆汁酸的胆汁分泌之间的相互关系。用该毒素处理并未显著改变胆汁磷脂分泌，这表明磷脂的转运主要是1区的功能。以1 μmol/（min·kg体重）的速率输注胆红素，在对照动物和处理过的动物中均引起胆汁磷脂分泌的显著抑制。以1.6 μmol/（min·kg体重）的速率额外输注甘氨脱氧胆酸钠可克服这种效应，尽管对照兔的磷脂输出增加幅度高于处理过的兔。这可能与溴苯损伤的肝脏中用于分泌的3区细胞募集减少有关。
