Westermark P, Wilander E
Diabetologia. 1978 Nov;15(5):417-21. doi: 10.1007/BF01219652.
Pancreatic islet volumes of patients with and without maturity onset diabetes mellitus were estimated. The islet volume of the diabetic patients was 1.01 +/- 0.12 cm3 (SEM) and that of the non-diabetic patients 1.60 +/- 0.16 cm3 with considerable overlap between the two groups. Islet amyloidosis was found in all the diabetic and in 9 of the 15 non-diabetic patients. When the amyloid deposits were excluded, the islet volume of the diabetic patients was 0.89 +/- 0.10 cm3, while that of the non-diabetic patients was unchanged, 1.60 +/- 0.16 cm3. There was still some overlapping. Since amyloid deposits seem to destroy the B cell membranes, it was postulated that a comparison of the volumes of islets completely free of amyloid might give a more true picture of the quantitative islet alterations in maturity onset diabetes. It was found that this islet volume of the diabetics was only 0.41 +/- 0.05 cm3 and that of the non-diabetic patients 1.58 +/- 0.16 cm3. These values correspond better to the altered insulin secretion in maturity-onset diabetes mellitus.
对患有和未患有成年型糖尿病的患者的胰岛体积进行了估算。糖尿病患者的胰岛体积为1.01±0.12立方厘米（标准误），非糖尿病患者的胰岛体积为1.60±0.16立方厘米，两组之间存在相当程度的重叠。在所有糖尿病患者以及15名非糖尿病患者中的9名患者中发现了胰岛淀粉样变性。当排除淀粉样沉积物后，糖尿病患者的胰岛体积为0.89±0.10立方厘米，而非糖尿病患者的胰岛体积未变，仍为1.60±0.16立方厘米。两者仍有一些重叠。由于淀粉样沉积物似乎会破坏B细胞膜，因此推测对完全不含淀粉样物质的胰岛体积进行比较，可能会更真实地反映成年型糖尿病中胰岛的定量改变情况。结果发现，糖尿病患者的这种胰岛体积仅为0.41±0.05立方厘米，而非糖尿病患者的胰岛体积为1.58±0.16立方厘米。这些数值与成年型糖尿病中胰岛素分泌的改变情况更为相符。
