Saito K, Takahashi T, Yaginuma N, Iwama N
Tohoku J Exp Med. 1978 Jun;125(2):185-97. doi: 10.1620/tjem.125.185.
Quantitative changes of the pancreatic islets in diabetes mellitus were analyzed by a stereological method. 26 maturity-onset and 5 growth-onset diabetics, and 37 nondiabetics including 9 hypertensives were selected from autopsy materials and the pancreases were subjected to histometry. The total islet volume Vi was 0.974 cm3 in the control, whereas it was only 0.596 and 0.255 cm3 in the maturity-onset and growth-onset diabetic groups, respectively. The hypertensive group gave almost the same value as the control. There was an obvious negative correlation between Vi and the maximum blood sugar level during glucose tolerance test, whether the case was diabetic or not. Moreover, in the diabetic group Vi diminished with descending age of onset. These findings indicate the importance of VI in the pathophysiology of diabetes and support the classical concept of insulin deficiency as the primary pathogenetic role. On the other hand, the total islet number Ni decreased with increasing mean radius r, and the diabetic and control cases shared a common regression of Ni on r. The diabetic pancreas was not characterized by Ni, r or by the distribution pattern of r.
采用体视学方法分析糖尿病患者胰岛的定量变化。从尸检材料中选取26例成年发病型糖尿病患者、5例幼年发病型糖尿病患者以及37例非糖尿病患者（包括9例高血压患者），对其胰腺进行组织测量。对照组的胰岛总体积Vi为0.974 cm³，而成年发病型糖尿病组和幼年发病型糖尿病组分别仅为0.596 cm³和0.255 cm³。高血压组的值与对照组几乎相同。无论病例是否为糖尿病患者，Vi与葡萄糖耐量试验期间的最高血糖水平之间均存在明显的负相关。此外，在糖尿病组中，Vi随着发病年龄的降低而减小。这些发现表明Vi在糖尿病病理生理学中的重要性，并支持胰岛素缺乏作为主要致病作用的经典概念。另一方面，胰岛总数Ni随着平均半径r的增加而减少，糖尿病患者和对照组的Ni与r之间存在共同的回归关系。糖尿病胰腺的特征不在于Ni、r或r的分布模式。
