血清咬合蛋白和封闭蛋白水平在注意缺陷多动障碍儿童和健康对照组中的研究。

Serum Occludin and Zonulin Levels in Children With Attention-Deficit/Hyperactivity Disorder and Healthy Controls.

机构信息

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Atatürk University, Erzurum, Turkey.

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Atatürk University, Erzurum, Turkey and Department of Child and Adolescent Psychiatry Child Study Center, NYU Langone Health, New York, USA. Correspondence to: Dr Hicran Doðru, Department of Child and Adolescent Psychiatry, Child Study Center, One Park Avenue, 7th Floor, New York, NY 10016, USA.

出版信息

Indian Pediatr. 2023 Feb 15;60(1):137-141.

PMID:36786182

Abstract

OBJECTIVE

To evaluate zonulin and occludin levels, potentially associated with immunological pathways in the gut-brain axis, in children with attention-deficit/hyperactivity disorder (ADHD).

METHOD

We examined the association between serum levels of zonulin and occluding, and behavioral/emotional problems in children with ADHD. 40 medication-naïve children meeting Diagnostic and statistical (DSM-5) criteria for ADHD (11 females; mean (SD) age 9.4 (1.6) years) and 39 healthy comparisons (12 females; mean (SD) age 9.3 (1.9) years) were studied. Serum zonulin and occludin levels were measured by (ELISA).

RESULTS

We found higher mean (SD) serum zonulin levels [37.1 (28.2) vs 8.1 (4.5) ng/mL; P<0.001) and occludin levels [2.4 (1.6) vs 0.6 (0.4) ng/mL; P<0.001] in the ADHD group compared to control group. Serum zonulin levels had a positive correlation with weight (r=0.452; P=0.003) and BMI (r=0.401; P=0.01) among children with ADHD. Serum zonulin and occludin levels also had a positive correlation with Conners parent rating scale scores (r=0.58; P<0.001), and Strengths and difficulties questionnaire scores (r=0.49; P<0.001). Multiple linear regression analysis revealed that age, sex, weight, conduct problems and oppositional sub-scores were significant predictors of increased serum zonulin levels.

CONCLUSION

These data confirm an association between ADHD, and serum zonulin and occludin levels. Pathophysiological and clinical significance of these findings needs to be elucidated.

摘要

目的

评估紧密连接蛋白和封闭蛋白水平，这些蛋白可能与肠-脑轴的免疫途径有关，在患有注意缺陷多动障碍（ADHD）的儿童中。

方法

我们研究了血清紧密连接蛋白和封闭蛋白水平与 ADHD 儿童行为/情绪问题之间的关系。40 名未服用药物的符合 ADHD 诊断和统计手册（DSM-5）标准的儿童（11 名女性；平均（SD）年龄 9.4（1.6）岁）和 39 名健康对照组（12 名女性；平均（SD）年龄 9.3（1.9）岁）被纳入研究。通过（ELISA）测量血清中紧密连接蛋白和封闭蛋白的水平。

结果

我们发现 ADHD 组的血清紧密连接蛋白水平[37.1（28.2）比 8.1（4.5）ng/mL；P<0.001]和封闭蛋白水平[2.4（1.6）比 0.6（0.4）ng/mL；P<0.001]均高于对照组。ADHD 组中血清紧密连接蛋白水平与体重呈正相关（r=0.452；P=0.003）和 BMI（r=0.401；P=0.01）。血清紧密连接蛋白和封闭蛋白水平与 Conners 父母评定量表评分（r=0.58；P<0.001）和困难问卷评分（r=0.49；P<0.001）也呈正相关。多元线性回归分析显示，年龄、性别、体重、行为问题和对立亚量表得分是血清紧密连接蛋白水平升高的显著预测因子。